Parasitic helminths and the host microbiome – A missing ‘extracellular vesicle-sized’ link?
View / Open Files
Authors
Rooney, James
Northcote, Holly Marie
Williams, Tim
Cortés, Alba
Morphew, Russ
Journal Title
Trends in Parasitology
ISSN
1471-4922
Publisher
Elsevier
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Rooney, J., Northcote, H. M., Williams, T., Cortés, A., Cantacessi, C., & Morphew, R. Parasitic helminths and the host microbiome – A missing ‘extracellular vesicle-sized’ link?. Trends in Parasitology https://doi.org/10.17863/CAM.85580
Abstract
Infections by gastrointestinal helminths have been associated with significant alterations of the structure of microbial communities inhabiting the host gut. However, current understanding of the biological mechanisms that regulate these relationships is still lacking. We propose that helminth-derived extracellular vesicles (EVs) likely represent key players in helminth-microbiota crosstalk. Here, we explore knowledge of helminth EVs, with an emphasis on their putative antimicrobial properties, and argue that (i) an enhanced understanding of the mechanisms governing such interactions might assist the discovery and development of novel strategies of parasite control; and that (ii) the identification and characterisation of helminth molecules with antimicrobial properties might pave the way towards the discovery of novel antibiotics, thus aiding the global fight against antimicrobial resistance.
Embargo Lift Date
2025-06-16
Identifiers
This record's DOI: https://doi.org/10.17863/CAM.85580
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338169
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.