Parasitic helminths and the host microbiome - a missing 'extracellular vesicle-sized' link?
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Authors
Rooney, James
Northcote, Holly M
Williams, Tim L
Cortés, Alba
Morphew, Russell M
Publication Date
2022-09Journal Title
Trends Parasitol
ISSN
1471-4922
Publisher
Elsevier BV
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Rooney, J., Northcote, H. M., Williams, T. L., Cortés, A., Cantacessi, C., & Morphew, R. M. (2022). Parasitic helminths and the host microbiome - a missing 'extracellular vesicle-sized' link?. Trends Parasitol https://doi.org/10.1016/j.pt.2022.06.003
Abstract
Infections by gastrointestinal (GI) helminths have been associated with significant alterations of the structure of microbial communities inhabiting the host gut. However, current understanding of the biological mechanisms that regulate these relationships is still lacking. We propose that helminth-derived extracellular vesicles (EVs) likely represent key players in helminth-microbiota crosstalk. Here, we explore knowledge of helminth EVs with an emphasis on their putative antimicrobial properties, and we argue that (i) an enhanced understanding of the mechanisms governing such interactions might assist the discovery and development of novel strategies of parasite control, and that (ii) the identification and characterisation of helminth molecules with antimicrobial properties might pave the way towards the discovery of novel antibiotics, thus aiding the global fight against antimicrobial resistance.
Keywords
antimicrobial peptides, excretory/secretory products, extracellular vesicles, helminth–microbiota crosstalk, host–helminth communication, Animals, Extracellular Vesicles, Helminths, Microbiota
Embargo Lift Date
2023-07-09
Identifiers
External DOI: https://doi.org/10.1016/j.pt.2022.06.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338169
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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