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dc.contributor.authorJung, JeYoung
dc.contributor.authorLambon Ralph, Matthew A
dc.date.accessioned2022-06-21T23:30:56Z
dc.date.available2022-06-21T23:30:56Z
dc.date.issued2022-05-21
dc.identifier.issn1047-3211
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338277
dc.description.abstractSemantic cognition is a complex multifaceted brain function involving multiple processes including sensory, semantic, and domain-general cognitive systems. However, it remains unclear how these systems cooperate with each other to achieve effective semantic cognition. Here, we used independent component analysis (ICA) to investigate the functional brain networks that support semantic cognition. We used a semantic judgment task and a pattern-matching control task, each with 2 levels of difficulty, to disentangle task-specific networks from domain-general networks. ICA revealed 2 task-specific networks (the left-lateralized semantic network [SN] and a bilateral, extended semantic network [ESN]) and domain-general networks including the frontoparietal network (FPN) and default mode network (DMN). SN was coupled with the ESN and FPN but decoupled from the DMN, whereas the ESN was synchronized with the FPN alone and did not show a decoupling with the DMN. The degree of decoupling between the SN and DMN was associated with semantic task performance, with the strongest decoupling for the poorest performing participants. Our findings suggest that human higher cognition is achieved by the multiple brain networks, serving distinct and shared cognitive functions depending on task demands, and that the neural dynamics between these networks may be crucial for efficient semantic cognition.
dc.format.mediumPrint-Electronic
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdefault mode network (DMN)
dc.subjectfrontoparietal network (FPN)
dc.subjectfunctional brain networks
dc.subjectindependent component analysis (ICA)
dc.subjectsemantic cognition
dc.titleDistinct but cooperating brain networks supporting semantic cognition.
dc.typeArticle
dc.publisher.departmentDepartment of Psychiatry
dc.date.updated2022-06-21T08:00:12Z
prism.publicationDate2022
prism.publicationNameCereb Cortex
prism.startingPagebhac190
dc.identifier.doi10.17863/CAM.85685
dcterms.dateAccepted2022-04-07
rioxxterms.versionofrecord10.1093/cercor/bhac190
rioxxterms.versionVoR
dc.contributor.orcidLambon Ralph, Matthew A [0000-0001-5907-2488]
dc.identifier.eissn1460-2199
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/R023883/1)
pubs.funder-project-idEuropean Research Council (670428)
cam.issuedOnline2022-05-21
cam.depositDate2022-06-21
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International