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dc.contributor.authorGillespie, David C
dc.contributor.authorHalai, Ajay
dc.contributor.authorWest, Robert M
dc.contributor.authorDickie, David A
dc.contributor.authorWalters, Matthew
dc.contributor.authorBroomfield, Niall M
dc.date.accessioned2022-06-22T23:30:34Z
dc.date.available2022-06-22T23:30:34Z
dc.date.issued2022-05-15
dc.identifier.issn0022-510X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338305
dc.description.abstractINTRODUCTION: Post stroke emotionalism (PSE) is a common but poorly understood condition. The value of altered brain structure as a putative risk factor for PSE alongside routinely available demographic and clinical variables has yet to be elucidated. METHODS: 85 patients were recruited from acute inpatient settings within 2 weeks of stroke. PSE was diagnosed using a validated semi-structured interview and standardised measures of stroke severity, functional ability, cognition, mood and quality of life were obtained. Neuroimaging variables (intracranial volume and volumes of cortical grey matter, subcortical grey matter, normal appearing white matter, cerebrum, cerebrospinal fluid and stroke; white matter hyperintensities; and mean cortical thickness) were derived using standardised methods from Magnetic Resonance Imaging (MRI) studies. The relationships between PSE diagnosis, brain structure, demographic and clinical variables were investigated using machine learning algorithms to determine how well different sets of predictors could classify PSE. RESULTS: The model with the best performance was derived from neuroradiological variables alone (sensitivity = 0.75; specificity = 0.8235), successfully classifying 9/12 individuals with PSE and 28/34 non-PSE cases. CONCLUSIONS: Neuroimaging measures appear to be important in PSE. Future work is needed to determine which specific variables are key. Imaging may complement standard behavioural measures and aid clinicians and researchers.
dc.format.mediumPrint-Electronic
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEmotionalism
dc.subjectNeuroimaging
dc.subjectPsychological outcomes
dc.subjectStroke
dc.subjectEmotions
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectNeuroimaging
dc.subjectQuality of Life
dc.subjectStroke
dc.subjectWhite Matter
dc.titleDemographic, clinical and neuroimaging markers of post-stroke emotionalism: A preliminary investigation.
dc.typeArticle
dc.publisher.departmentMrc Cognition And Brain Sciences Unit
dc.date.updated2022-06-22T09:11:47Z
prism.number120229
prism.publicationDate2022
prism.publicationNameJ Neurol Sci
prism.startingPage120229
prism.volume436
dc.identifier.doi10.17863/CAM.85714
dcterms.dateAccepted2022-03-11
rioxxterms.versionofrecord10.1016/j.jns.2022.120229
rioxxterms.versionVoR
dc.identifier.eissn1878-5883
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (MR/V031481/1)
cam.depositDate2022-06-22
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International