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dc.contributor.authorHumphreys, Gina F
dc.contributor.authorJung, JeYoung
dc.contributor.authorLambon Ralph, Matthew A
dc.date.accessioned2022-06-22T23:31:04Z
dc.date.available2022-06-22T23:31:04Z
dc.date.issued2022-12-08
dc.identifier.issn1047-3211
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338315
dc.description.abstractDecades of research have highlighted the importance of lateral parietal cortex (LPC) across a myriad of cognitive domains. Yet, the underlying function of LPC remains unclear. Two domains that have emphasized LPC involvement are semantic memory and episodic memory retrieval. From each domain, sophisticated functional models have been proposed, as well as the more domain-general assumption that LPC is engaged by any form of internally directed cognition (episodic/semantic retrieval being examples). Here we used a combination of functional magnetic resonance imaging, functional connectivity, and diffusion tensor imaging white-matter connectivity to show that (i) ventral LPC (angular gyrus [AG]) was positively engaged during episodic retrieval but disengaged during semantic memory retrieval and (ii) activity negatively varied with task difficulty in the semantic task whereas episodic activation was independent of difficulty. In contrast, dorsal LPC (intraparietal sulcus) showed domain general activation that was positively correlated with task difficulty. Finally, (iii) a dorsal-ventral and anterior-posterior gradient of functional and structural connectivity was found across the AG (e.g. mid-AG connected with episodic retrieval). We propose a unifying model in which LPC as a whole might share a common underlying neurocomputation (multimodal buffering) with variations in the emergent cognitive functions across subregions arising from differences in the underlying connectivity.
dc.format.mediumPrint-Electronic
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectangular gyrus
dc.subjectepisodic
dc.subjectfMRI
dc.subjectparietal
dc.subjectsemantic
dc.titleThe convergence and divergence of episodic and semantic functions across lateral parietal cortex.
dc.typeArticle
dc.publisher.departmentMrc Cognition And Brain Sciences Unit
dc.publisher.departmentDepartment of Psychiatry
dc.date.updated2022-06-22T10:30:21Z
prism.publicationDate2022
prism.publicationNameCereb Cortex
prism.startingPagebhac044
dc.identifier.doi10.17863/CAM.85724
dcterms.dateAccepted2022-01-22
rioxxterms.versionofrecord10.1093/cercor/bhac044
rioxxterms.versionVoR
dc.contributor.orcidLambon Ralph, Matthew A [0000-0001-5907-2488]
dc.identifier.eissn1460-2199
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/R023883/1)
cam.issuedOnline2022-02-23
cam.depositDate2022-06-22
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International