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dc.contributor.authorGrootes, Isabelle
dc.contributor.authorKeeman, Renske
dc.contributor.authorBlows, Fiona M
dc.contributor.authorMilne, Roger L
dc.contributor.authorGiles, Graham G
dc.contributor.authorSwerdlow, Anthony J
dc.contributor.authorFasching, Peter A
dc.contributor.authorAbubakar, Mustapha
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorBojesen, Stig E
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorBriceno, Ignacio
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorCamp, Nicola J
dc.contributor.authorCastelao, Jose E
dc.contributor.authorChoi, Ji-Yeob
dc.contributor.authorClarke, Christine L
dc.contributor.authorCouch, Fergus J
dc.contributor.authorCox, Angela
dc.contributor.authorCross, Simon S
dc.contributor.authorCzene, Kamila
dc.contributor.authorDevilee, Peter
dc.contributor.authorDörk, Thilo
dc.contributor.authorDunning, Alison M
dc.contributor.authorDwek, Miriam
dc.contributor.authorEaston, Douglas F
dc.contributor.authorEccles, Diana M
dc.contributor.authorEriksson, Mikael
dc.contributor.authorErnst, Kristina
dc.contributor.authorEvans, D Gareth
dc.contributor.authorFigueroa, Jonine D
dc.contributor.authorFink, Visnja
dc.contributor.authorFloris, Giuseppe
dc.contributor.authorFox, Stephen
dc.contributor.authorGabrielson, Marike
dc.contributor.authorGago-Dominguez, Manuela
dc.contributor.authorGarcía-Sáenz, José A
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorHaeberle, Lothar
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorHall, Per
dc.contributor.authorHamann, Ute
dc.contributor.authorHarkness, Elaine F
dc.contributor.authorHartman, Mikael
dc.contributor.authorHein, Alexander
dc.contributor.authorHooning, Maartje J
dc.contributor.authorHou, Ming-Feng
dc.contributor.authorHowell, Sacha J
dc.contributor.authorABCTB Investigators
dc.contributor.authorkConFab Investigators
dc.contributor.authorIto, Hidemi
dc.contributor.authorJakubowska, Anna
dc.contributor.authorJanni, Wolfgang
dc.contributor.authorJohn, Esther M
dc.contributor.authorJung, Audrey
dc.contributor.authorKang, Daehee
dc.contributor.authorKristensen, Vessela N
dc.contributor.authorKwong, Ava
dc.contributor.authorLambrechts, Diether
dc.contributor.authorLi, Jingmei
dc.contributor.authorLubiński, Jan
dc.contributor.authorManoochehri, Mehdi
dc.contributor.authorMargolin, Sara
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorTaib, Nur Aishah Mohd
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorNewman, William G
dc.contributor.authorOffit, Kenneth
dc.contributor.authorOsorio, Ana
dc.contributor.authorPark, Sue K
dc.contributor.authorPark-Simon, Tjoung-Won
dc.contributor.authorPatel, Alpa V
dc.contributor.authorPresneau, Nadege
dc.contributor.authorPylkäs, Katri
dc.contributor.authorRack, Brigitte
dc.contributor.authorRadice, Paolo
dc.contributor.authorRennert, Gad
dc.contributor.authorRomero, Atocha
dc.contributor.authorSaloustros, Emmanouil
dc.contributor.authorSawyer, Elinor J
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorSchochter, Fabienne
dc.contributor.authorSchoemaker, Minouk J
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorShibli, Rana
dc.contributor.authorSinn, Peter
dc.contributor.authorTapper, William J
dc.contributor.authorTawfiq, Essa
dc.contributor.authorTeo, Soo Hwang
dc.contributor.authorTeras, Lauren R
dc.contributor.authorTorres, Diana
dc.contributor.authorVachon, Celine M
dc.contributor.authorvan Deurzen, Carolien HM
dc.contributor.authorWendt, Camilla
dc.contributor.authorWilliams, Justin A
dc.contributor.authorWinqvist, Robert
dc.contributor.authorElwood, Mark
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorPharoah, Paul DP
dc.date.accessioned2022-06-27T23:30:19Z
dc.date.available2022-06-27T23:30:19Z
dc.date.issued2022-09
dc.identifier.issn0959-8049
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338372
dc.description.abstractBACKGROUND: Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of PREDICT and to compare its performance to the current version (2.2). METHOD: The prognostic effect of PR status was based on the analysis of data from 45,088 European patients with breast cancer from 49 studies in the Breast Cancer Association Consortium. Cox proportional hazard models were used to estimate the hazard ratio for PR status. Data from a New Zealand study of 11,365 patients with early invasive breast cancer were used for external validation. Model calibration and discrimination were used to test the model performance. RESULTS: Having a PR-positive tumour was associated with a 23% and 28% lower risk of dying from breast cancer for women with oestrogen receptor (ER)-negative and ER-positive breast cancer, respectively. The area under the ROC curve increased with the addition of PR status from 0.807 to 0.809 for patients with ER-negative tumours (p = 0.023) and from 0.898 to 0.902 for patients with ER-positive tumours (p = 2.3 × 10-6) in the New Zealand cohort. Model calibration was modest with 940 observed deaths compared to 1151 predicted. CONCLUSION: The inclusion of the prognostic effect of PR status to PREDICT Breast has led to an improvement of model performance and more accurate absolute treatment benefit predictions for individual patients. Further studies should determine whether the baseline hazard function requires recalibration.
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleIncorporating progesterone receptor expression into the PREDICT breast prognostic model.
dc.typeArticle
dc.publisher.departmentDepartment of Public Health And Primary Care, Cancer Genetic Epidemiology
dc.date.updated2022-06-22T07:26:22Z
prism.publicationNameEur J Cancer
dc.identifier.doi10.17863/CAM.85784
dcterms.dateAccepted2022-06-03
rioxxterms.versionofrecord10.1016/j.ejca.2022.06.011
rioxxterms.versionAM
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.identifier.eissn1879-0852
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (633784)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (634935)
pubs.funder-project-idWellcome Trust (203477/Z/16/Z)
cam.issuedOnline2022-08-04
cam.orpheus.successMon Aug 15 07:57:15 BST 2022 - Embargo updated
cam.orpheus.counter4
cam.depositDate2022-06-22
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-08-04


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International