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dc.contributor.authorMcDermott, Samuel
dc.contributor.authorAyazi, Filip
dc.contributor.authorCollins, Joel
dc.contributor.authorKnapper, Joe
dc.contributor.authorStirling, Julian
dc.contributor.authorBowman, Richard
dc.contributor.authorCicuta, Pietro
dc.date.accessioned2022-06-27T23:30:26Z
dc.date.available2022-06-27T23:30:26Z
dc.date.issued2022-07-18
dc.identifier.issn1094-4087
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338374
dc.description.abstractMicroscopes are vital pieces of equipment in much of biological research and medical diagnostics. However, access to a microscope can represent a bottleneck in research, especially in lower-income countries. 'Smart' computer controlled motorized microscopes, which can perform automated routines or acquire images in a range of modalities are even more expensive and inaccessible. Developing low-cost, open-source, smart microscopes enables more researchers to conceive and execute optimized or more complex experiments. Here we present the OpenFlexure Delta Stage, a 3D-printed microscope designed for researchers. Powered by the OpenFlexure software stack, it is capable of performing automated experiments. The design files and assembly instructions are freely available under an open licence. Its intuitive and modular design-along with detailed documentation-allows researchers to implement a variety of imaging modes with ease. The versatility of this microscope is demonstrated by imaging biological and non-biological samples (red blood cells with Plasmodium parasites and colloidal particles in brightfield, epi-fluorescence, darkfield, Rheinberg and differential phase contrast. We present the design strategy and choice of tools to develop devices accessible to researchers from lower-income countries, as well as the advantages of an open-source project in this context. This microscope, having been open-source since its conception, has already been built and tested by researchers around the world, promoting a community of expertise and an environment of reproducibility in science.
dc.publisherOptica Publishing Group
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjectphysics.ins-det
dc.subjectphysics.ins-det
dc.subjectphysics.optics
dc.titleMulti-modal microscopy imaging with the OpenFlexure Delta Stage.
dc.typeArticle
dc.publisher.departmentDepartment of Physics
dc.date.updated2022-06-24T08:29:49Z
prism.publicationNameOpt Express
dc.identifier.doi10.17863/CAM.85786
dcterms.dateAccepted2022-06-14
rioxxterms.versionofrecord10.1364/OE.450211
rioxxterms.versionAM
dc.contributor.orcidMcDermott, Samuel [0000-0003-2736-5467]
dc.contributor.orcidCicuta, Pietro [0000-0002-9193-8496]
dc.identifier.eissn1094-4087
dc.publisher.urlhttp://dx.doi.org/10.1364/OE.450211
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/R011443/1)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/R013969/1)
cam.issuedOnline2022-07-06
cam.orpheus.successWed Aug 03 09:45:55 BST 2022 - Embargo updated
cam.orpheus.counter2
cam.depositDate2022-06-24
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-06-14


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