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A Case of Thrombotic Microangiopathy and Acute Sarcoidosis.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Martinelli, Anthony W 
Dunn, William 
McClure, Mark E 
Walker, Ieuan 
Stewart, Andrew 

Abstract

Although sarcoidosis is an established cause of multiorgan dysfunction, acute presentation with thrombotic microangiopathy resulting in severe renal and hematological sequelae has not been reported. We describe the case of a patient presenting with hypercalcemia, pancreatitis, and acute renal failure, followed by microangiopathic hemolytic anemia. Although there were no significant respiratory symptoms, thoracic radiology and mediastinal lymph node biopsy results were in keeping with sarcoidosis as the underlying cause of this multisystem presentation. Corticosteroids were commenced with clinical and biochemical improvement. This novel case highlights the need to consider sarcoidosis as part of the differential diagnosis for unusual multiorgan presentations and for early multidisciplinary involvement in such cases to permit optimal treatment.

Description

Keywords

Hemolytic anemia, ILD, MAHA, TMA, sarcoidosis, thrombotic microangiopathy, Humans, Thrombotic Microangiopathies, Kidney, Acute Kidney Injury, Biopsy, Sarcoidosis

Journal Title

Chest

Conference Name

Journal ISSN

0012-3692
1931-3543

Volume Title

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (215477/Z/19/Z)
AWM is supported by a Wellcome Trust Clinical PhD training fellowship (220535/Z/20/Z). JAN is supported by a Wellcome Trust Senior Research Fellowship (215477/Z/19/Z) and by the Lister Institute.