A Case of Thrombotic Microangiopathy and Acute Sarcoidosis.
Martinelli, Anthony W
McClure, Mark E
Preston, Stephen D
Nathan, James A
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Martinelli, A. W., Dunn, W., McClure, M. E., Walker, I., Stewart, A., Karia, S., Preston, S. D., et al. (2022). A Case of Thrombotic Microangiopathy and Acute Sarcoidosis.. Chest https://doi.org/10.1016/j.chest.2022.06.023
Although sarcoidosis is an established cause of multiorgan dysfunction, acute presentation with thrombotic microangiopathy resulting in severe renal and hematological sequelae has not been reported. We describe the case of a patient presenting with hypercalcemia, pancreatitis, and acute renal failure, followed by microangiopathic hemolytic anemia. Although there were no significant respiratory symptoms, thoracic radiology and mediastinal lymph node biopsy results were in keeping with sarcoidosis as the underlying cause of this multisystem presentation. Corticosteroids were commenced with clinical and biochemical improvement. This novel case highlights the need to consider sarcoidosis as part of the differential diagnosis for unusual multiorgan presentations and for early multidisciplinary involvement in such cases to permit optimal treatment.
AWM is supported by a Wellcome Trust Clinical PhD training fellowship (220535/Z/20/Z). JAN is supported by a Wellcome Trust Senior Research Fellowship (215477/Z/19/Z) and by the Lister Institute.
Wellcome Trust (215477/Z/19/Z)
External DOI: https://doi.org/10.1016/j.chest.2022.06.023
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338381
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/