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dc.contributor.authorGarcés, Pilar
dc.contributor.authorBaumeister, Sarah
dc.contributor.authorMason, Luke
dc.contributor.authorChatham, Christopher H
dc.contributor.authorHoliga, Stefan
dc.contributor.authorDukart, Juergen
dc.contributor.authorJones, Emily JH
dc.contributor.authorBanaschewski, Tobias
dc.contributor.authorBaron-Cohen, Simon
dc.contributor.authorBölte, Sven
dc.contributor.authorBuitelaar, Jan K
dc.contributor.authorDurston, Sarah
dc.contributor.authorOranje, Bob
dc.contributor.authorPersico, Antonio M
dc.contributor.authorBeckmann, Christian F
dc.contributor.authorBougeron, Thomas
dc.contributor.authorDell'Acqua, Flavio
dc.contributor.authorEcker, Christine
dc.contributor.authorMoessnang, Carolin
dc.contributor.authorCharman, Tony
dc.contributor.authorTillmann, Julian
dc.contributor.authorMurphy, Declan GM
dc.contributor.authorJohnson, Mark
dc.contributor.authorLoth, Eva
dc.contributor.authorBrandeis, Daniel
dc.contributor.authorHipp, Joerg F
dc.contributor.authorEU-AIMS LEAP group authorship
dc.description.abstractBACKGROUND: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but results are inconsistent. Unbiased investigation in large and comprehensive samples focusing on replicability is needed. METHODS: We quantified resting state EEG alpha peak metrics, power spectrum (PS, 2-32 Hz) and functional connectivity (FC) in 411 children, adolescents and adults (n = 212 ASD, n = 199 neurotypicals [NT], all with IQ > 75). We performed analyses in source-space using individual head models derived from the participants' MRIs. We tested for differences in mean and variance between the ASD and NT groups for both PS and FC using linear mixed effects models accounting for age, sex, IQ and site effects. Then, we used machine learning to assess whether a multivariate combination of EEG features could better separate ASD and NT participants. All analyses were embedded within a train-validation approach (70%-30% split). RESULTS: In the training dataset, we found an interaction between age and group for the reactivity to eye opening (p = .042 uncorrected), and a significant but weak multivariate ASD vs. NT classification performance for PS and FC (sensitivity 0.52-0.62, specificity 0.59-0.73). None of these findings replicated significantly in the validation dataset, although the effect size in the validation dataset overlapped with the prediction interval from the training dataset. LIMITATIONS: The statistical power to detect weak effects-of the magnitude of those found in the training dataset-in the validation dataset is small, and we cannot fully conclude on the reproducibility of the training dataset's effects. CONCLUSIONS: This suggests that PS and FC values in ASD and NT have a strong overlap, and that differences between both groups (in both mean and variance) have, at best, a small effect size. Larger studies would be needed to investigate and replicate such potential effects.
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.sourceessn: 2040-2392
dc.sourcenlmid: 101534222
dc.subjectPower spectrum
dc.subjectResting state
dc.subjectAutism Spectrum Disorder
dc.subjectFunctional Connectivity
dc.subjectMagnetic Resonance Imaging
dc.subjectBrain Mapping
dc.subjectCross-Sectional Studies
dc.subjectReproducibility of Results
dc.subjectAutistic Disorder
dc.titleResting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis.
prism.publicationNameMol Autism
dc.contributor.orcidGarcés, Pilar [0000-0003-4989-0123]

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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International