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dc.contributor.authorHemady, Chad Lance
dc.contributor.authorSpeyer, Lydia Gabriela
dc.contributor.authorMurray, Aja Louise
dc.contributor.authorBrown, Ruth Harriet
dc.contributor.authorMeinck, Franziska
dc.contributor.authorFry, Deborah
dc.contributor.authorDo, Huyen
dc.contributor.authorSikander, Siham
dc.contributor.authorMadrid, Bernadette
dc.contributor.authorFernando, Asvini
dc.contributor.authorWalker, Susan
dc.contributor.authorDunne, Michael
dc.contributor.authorFoley, Sarah
dc.contributor.authorHughes, Claire
dc.contributor.authorOsafo, Joseph
dc.contributor.authorBaban, Adriana
dc.contributor.authorTaut, Diana
dc.contributor.authorWard, Catherine L
dc.contributor.authorVan Thang, Vo
dc.contributor.authorFearon, Pasco
dc.contributor.authorTomlinson, Mark
dc.contributor.authorValdebenito, Sara
dc.contributor.authorEisner, Manuel
dc.date.accessioned2022-06-29T19:44:14Z
dc.date.available2022-06-29T19:44:14Z
dc.date.issued2022-06-22
dc.date.submitted2021-11-04
dc.identifier.issn1471-2393
dc.identifier.others12884-022-04839-0
dc.identifier.other4839
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338474
dc.descriptionFunder: Edinburgh Centre for Data, Culture and Society
dc.description.abstractBACKGROUND: This paper enumerates and characterizes latent classes of adverse childhood experiences and investigates how they relate to prenatal substance use (i.e., smoking, alcohol, and other drugs) and poor infant outcomes (i.e., infant prematurity and low birthweight) across eight low- and middle-income countries (LMICs). METHODS: A total of 1189 mother-infant dyads from the Evidence for Better Lives Study cohort were recruited. Latent class analysis using the Bolck, Croon, and Hagenaars (BCH) 3-step method with auxiliary multilevel logistic regressions was performed. RESULTS: Three high-risk classes and one low-risk class emerged: (1) highly maltreated (7%, n = 89), (2) emotionally and physically abused with intra-familial violence exposure (13%, n = 152), (3), emotionally abused (40%, n = 474), and (4) low household dysfunction and abuse (40%, n = 474). Pairwise comparisons between classes indicate higher probabilities of prenatal drug use in the highly maltreated and emotionally abused classes compared with the low household dysfunction and abuse class. Additionally, the emotionally and physically abused with intra-familial violence exposure class had higher probability of low birthweight than the three remaining classes. CONCLUSION: Our results highlight the multifaceted nature of ACEs and underline the potential importance of exposure to childhood adversities on behaviors and outcomes in the perinatal period. This can inform the design of antenatal support to better address these challenges.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectResearch
dc.subjectAdverse childhood experiences
dc.subjectLatent class analysis
dc.subjectMaternal health
dc.subjectNeonatal health
dc.subjectPrenatal substance use
dc.subjectIntergenerational transmission of adversity
dc.titlePatterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis.
dc.typeArticle
dc.date.updated2022-06-29T19:44:14Z
prism.issueIdentifier1
prism.publicationNameBMC Pregnancy Childbirth
prism.volume22
dc.identifier.doi10.17863/CAM.85887
dcterms.dateAccepted2022-06-13
rioxxterms.versionofrecord10.1186/s12884-022-04839-0
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidEisner, Manuel [0000-0001-5436-9282]
dc.identifier.eissn1471-2393
pubs.funder-project-idEuropean Research Council (852787)
pubs.funder-project-idUK Research and Innovation Global Challenges Research Fund (ES/S008101/1)
cam.issuedOnline2022-06-22


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