Show simple item record

dc.contributor.authorChen, Joshua C
dc.contributor.authorKan, Peter
dc.contributor.authorYu, Zhanghao
dc.contributor.authorAlrashdan, Fatima
dc.contributor.authorGarcia, Roberto
dc.contributor.authorSinger, Amanda
dc.contributor.authorLai, CS Edwin
dc.contributor.authorAvants, Ben
dc.contributor.authorCrosby, Scott
dc.contributor.authorLi, Zhongxi
dc.contributor.authorWang, Boshuo
dc.contributor.authorFelicella, Michelle M
dc.contributor.authorRobledo, Ariadna
dc.contributor.authorPeterchev, Angel V
dc.contributor.authorGoetz, Stefan M
dc.contributor.authorHartgerink, Jeffrey D
dc.contributor.authorSheth, Sunil A
dc.contributor.authorYang, Kaiyuan
dc.contributor.authorRobinson, Jacob T
dc.date.accessioned2022-06-29T19:44:24Z
dc.date.available2022-06-29T19:44:24Z
dc.date.issued2022-06
dc.date.submitted2021-07-06
dc.identifier.issn2157-846X
dc.identifier.others41551-022-00873-7
dc.identifier.other873
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338478
dc.descriptionFunder: NIH U18EB029353, NSF GRFP
dc.descriptionFunder: NIH U18EB029353
dc.descriptionFunder: NIH R01DE021798, NSF GRFP
dc.descriptionFunder: NIH R01DE021798
dc.description.abstractImplantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals' sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/639/166/985
dc.subject/631/378/1959
dc.subject/692/617/375
dc.subject/639/166/987
dc.subject/631/378/2607
dc.subjectarticle
dc.titleA wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves.
dc.typeArticle
dc.date.updated2022-06-29T19:44:24Z
prism.endingPage716
prism.issueIdentifier6
prism.publicationNameNat Biomed Eng
prism.startingPage706
prism.volume6
dc.identifier.doi10.17863/CAM.85891
dcterms.dateAccepted2022-02-15
rioxxterms.versionofrecord10.1038/s41551-022-00873-7
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidAlrashdan, Fatima [0000-0001-7605-1056]
dc.contributor.orcidGarcia, Roberto [0000-0001-8907-9867]
dc.contributor.orcidWang, Boshuo [0000-0003-1680-5957]
dc.contributor.orcidPeterchev, Angel V [0000-0002-4385-065X]
dc.contributor.orcidGoetz, Stefan M [0000-0002-1944-0714]
dc.contributor.orcidHartgerink, Jeffrey D [0000-0002-3186-5395]
dc.contributor.orcidSheth, Sunil A [0000-0003-0602-8509]
dc.contributor.orcidYang, Kaiyuan [0000-0001-7220-9389]
dc.contributor.orcidRobinson, Jacob T [0000-0002-3509-3054]
dc.identifier.eissn2157-846X
cam.issuedOnline2022-03-31


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record