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dc.contributor.authorLiu, Jie
dc.contributor.authorGao, Boya
dc.contributor.authorBao, Helen Xiaohui
dc.contributor.authorShi, Zhenwu
dc.date.accessioned2022-06-29T19:44:47Z
dc.date.available2022-06-29T19:44:47Z
dc.date.issued2022-06-20
dc.date.submitted2022-01-10
dc.identifier.issn2044-6055
dc.identifier.otherbmjopen-2022-060996
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338488
dc.description.abstractOBJECTIVE: By using a data-driven statistical approach, we isolated the net effect of multiple government interventions that were simultaneously implemented during the second wave of COVID-19 pandemic in China. DESIGN, DATA SOURCES AND ELIGIBILITY CRITERIA: We gathered epidemiological data and government interventions data of nine cities with local outbreaks during the second wave of COVID-19 pandemic in China. We employed the Susceptible-Exposed-Infectious-Recovered (SEIR) framework model to analyse the different pathways of transmission between cities with government interventions implementation and those without. We introduced new components to the standard SEIR model and investigated five themes of government interventions against COVID-19 pandemic. DATA EXTRACTION AND SYNTHESIS: We extracted information including study objective, design, methods, main findings and implications. These were tabulated and a narrative synthesis was undertaken given the diverse research designs, methods and implications. RESULTS: Supported by extensive empirical validation, our results indicated that the net effect of some specific government interventions (including masks, environmental cleaning and disinfection, tracing, tracking and 14-day centralised quarantining close contacts) had been significantly underestimated in the previous investigation. We also identified important moderators and mediators for the effect of certain government interventions, such as closure of shopping mall and restaurant in the medium-risk level areas, etc. Linking the COVID-19 epidemiological dynamics with the implementation timing of government interventions, we detected that the earlier implementation of some specific government interventions (including targeted partial lockdown, tracing, tracking and 14-day centralised quarantining close contacts) achieved the strongest and most timely effect on controlling COVID-19, especially at the early period of local outbreak. CONCLUSIONS: These findings provide important scientific information for decisions regarding which and when government interventions should be implemented to fight against COVID-19 in China and beyond. The proposed analytical framework is useful for policy-making in future endemic and pandemic as well.
dc.languageen
dc.publisherBMJ
dc.subjectHealth policy
dc.subject1506
dc.subject2474
dc.subject1703
dc.subjectCOVID-19
dc.subjectepidemiology
dc.subjecthealth policy
dc.subjectpublic health
dc.titleIsolating the net effect of multiple government interventions with an extended Susceptible-Exposed-Infectious-Recovered (SEIR) framework: empirical evidence from the second wave of COVID-19 pandemic in China.
dc.typeArticle
dc.date.updated2022-06-29T19:44:46Z
prism.issueIdentifier6
prism.publicationNameBMJ Open
prism.volume12
dc.identifier.doi10.17863/CAM.85901
dcterms.dateAccepted2022-05-06
rioxxterms.versionofrecord10.1136/bmjopen-2022-060996
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.licenseref.startdate2022-06-20
dc.contributor.orcidLiu, Jie [0000-0002-7020-9702]
dc.identifier.eissn2044-6055
pubs.funder-project-idNational Social Science Foundation of China (20CGL051)
cam.issuedOnline2022-06-20
rioxxterms.freetoread.startdate2022-06-20
rioxxterms.freetoread.startdate2022-06-20


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