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dc.contributor.authorLurette, Olivier
dc.contributor.authorGuedouari, Hala
dc.contributor.authorMorris, Jordan L.
dc.contributor.authorMartín-Jiménez, Rebeca
dc.contributor.authorRobichaud, Julie-Pier
dc.contributor.authorHamel-Côté, Geneviève
dc.contributor.authorKhan, Mehtab
dc.contributor.authorDauphinee, Nicholas
dc.contributor.authorPichaud, Nicolas
dc.contributor.authorPrudent, Julien
dc.contributor.authorHebert-Chatelain, Etienne
dc.date.accessioned2022-06-29T19:46:38Z
dc.date.available2022-06-29T19:46:38Z
dc.date.issued2022-05-30
dc.date.submitted2021-11-15
dc.identifier.issn1420-682X
dc.identifier.others00018-022-04325-y
dc.identifier.other4325
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338522
dc.description.abstractAbstract: The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress. Understanding how these events are regulated is important to elucidate how mitochondrial dynamics control cell fate. Here, we show that the tyrosine kinase Src regulates mitochondrial morphology. Deletion of Src increased mitochondrial size and reduced cellular respiration independently of mitochondrial mass, mitochondrial membrane potential or ATP levels. Re-expression of Src targeted to the mitochondrial matrix, but not of Src targeted to the plasma membrane, rescued mitochondrial morphology in a kinase activity-dependent manner. These findings highlight a novel function for Src in the control of mitochondrial dynamics.
dc.languageen
dc.publisherSpringer International Publishing
dc.subjectOriginal Article
dc.subjectMitochondrial dynamics
dc.subjectCellular respiration
dc.subjectMitochondria-shaping protein
dc.subjectOxidative phosphorylation
dc.titleMitochondrial matrix-localized Src kinase regulates mitochondrial morphology
dc.typeArticle
dc.date.updated2022-06-29T19:46:38Z
prism.issueIdentifier6
prism.publicationNameCellular and Molecular Life Sciences
prism.volume79
dc.identifier.doi10.17863/CAM.85935
dcterms.dateAccepted2022-04-22
rioxxterms.versionofrecord10.1007/s00018-022-04325-y
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidHebert-Chatelain, Etienne [0000-0003-1480-2787]
dc.identifier.eissn1420-9071


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