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dc.contributor.authorDesjardins, Stuart D
dc.contributor.authorSimmonds, James
dc.contributor.authorGuterman, Inna
dc.contributor.authorKanyuka, Kostya
dc.contributor.authorBurridge, Amanda J
dc.contributor.authorTock, Andrew
dc.contributor.authorSanchez-Moran, Eugenio
dc.contributor.authorFranklin, F Chris H
dc.contributor.authorHenderson, Ian
dc.contributor.authorEdwards, Keith J
dc.contributor.authorUauy, Cristobal
dc.contributor.authorHiggins, James D
dc.date.accessioned2022-06-29T19:46:48Z
dc.date.available2022-06-29T19:46:48Z
dc.date.issued2022-06-25
dc.date.submitted2022-02-22
dc.identifier.issn2041-1723
dc.identifier.others41467-022-31438-6
dc.identifier.other31438
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338526
dc.description.abstractFANCM suppresses crossovers in plants by unwinding recombination intermediates. In wheat, crossovers are skewed toward the chromosome ends, thus limiting generation of novel allelic combinations. Here, we observe that FANCM maintains the obligate crossover in tetraploid and hexaploid wheat, thus ensuring that every chromosome pair exhibits at least one crossover, by localizing class I crossover protein HEI10 at pachytene. FANCM also suppresses class II crossovers that increased 2.6-fold in fancm msh5 quadruple mutants. These data are consistent with a role for FANCM in second-end capture of class I designated crossover sites, whilst FANCM is also required to promote formation of non-crossovers. In hexaploid wheat, genetic mapping reveals that crossovers increase by 31% in fancm compared to wild type, indicating that fancm could be an effective tool to accelerate breeding. Crossover rate differences in fancm correlate with wild type crossover distributions, suggesting that chromatin may influence the recombination landscape in similar ways in both wild type and fancm.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/208/1405
dc.subject/631/80/641/1633
dc.subject/631/449/2491
dc.subject/14/32
dc.subject/14/63
dc.subject/45
dc.subject/45/77
dc.subjectarticle
dc.titleFANCM promotes class I interfering crossovers and suppresses class II non-interfering crossovers in wheat meiosis.
dc.typeArticle
dc.date.updated2022-06-29T19:46:48Z
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume13
dc.identifier.doi10.17863/CAM.85939
dcterms.dateAccepted2022-06-17
rioxxterms.versionofrecord10.1038/s41467-022-31438-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSimmonds, James [0000-0003-4936-1694]
dc.contributor.orcidKanyuka, Kostya [0000-0001-6324-4123]
dc.contributor.orcidBurridge, Amanda J [0000-0002-0140-5523]
dc.contributor.orcidTock, Andrew [0000-0002-6590-8314]
dc.contributor.orcidHenderson, Ian [0000-0001-5066-1489]
dc.contributor.orcidUauy, Cristobal [0000-0002-9814-1770]
dc.contributor.orcidHiggins, James D [0000-0001-6027-8678]
dc.identifier.eissn2041-1723
pubs.funder-project-idRCUK | Biotechnology and Biological Sciences Research Council (BBSRC) (BB/M014908/1)
cam.issuedOnline2022-06-25


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