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dc.contributor.authorZimphango, Chisomo
dc.contributor.authorAlimagham, Farah C
dc.contributor.authorCarpenter, Keri LH
dc.contributor.authorHutchinson, Peter J
dc.contributor.authorHutter, Tanya
dc.date.accessioned2022-06-29T19:48:30Z
dc.date.available2022-06-29T19:48:30Z
dc.date.issued2022-04-26
dc.identifier.issn2218-1989
dc.identifier.other35629896
dc.identifier.otherPMC9146878
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338565
dc.description.abstractIn a traumatically injured brain, the cerebral microdialysis technique allows continuous sampling of fluid from the brain's extracellular space. The retrieved brain fluid contains useful metabolites that indicate the brain's energy state. Assessment of these metabolites along with other parameters, such as intracranial pressure, brain tissue oxygenation, and cerebral perfusion pressure, may help inform clinical decision making, guide medical treatments, and aid in the prognostication of patient outcomes. Currently, brain metabolites are assayed on bedside analysers and results can only be achieved hourly. This is a major drawback because critical information within each hour is lost. To address this, recent advances have focussed on developing biosensing techniques for integration with microdialysis to achieve continuous online monitoring. In this review, we discuss progress in this field, focusing on various types of sensing devices and their ability to quantify specific cerebral metabolites at clinically relevant concentrations. Important points that require further investigation are highlighted, and comments on future perspectives are provided.
dc.description.sponsorshipNational Institute for Health Research Invention for Innovation Awards (NIHR i4i Challenge Award and NIHR i4i Product Development Award) and the NIHR Brain Injury MedTech Co-operative. C.Z. is supported by a Research Studentship from the W.D. Armstrong Trust (Uni-versity of Cambridge). F.C.A. is supported by an NIHR i4i Product Development Award. K.L.H.C. is supported by the NIHR Biomedical Research Centre, Cambridge and by an NIHR i4i Product Development Award. P.J.H. is supported by the NIHR Biomedical Research Centre Cambridge, NIHR Senior Investigator Award, and the Royal College of Surgeons of England.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2218-1989
dc.sourcenlmid: 101578790
dc.subjectBiosensors
dc.subjectTraumatic brain injury
dc.subjectneurochemistry
dc.subjectCerebral Metabolism
dc.subjectCerebral Microdialysis
dc.titleMonitoring Neurochemistry in Traumatic Brain Injury Patients Using Microdialysis Integrated with Biosensors: A Review.
dc.typeArticle
dc.date.updated2022-06-29T19:48:30Z
prism.issueIdentifier5
prism.publicationNameMetabolites
prism.volume12
dc.identifier.doi10.17863/CAM.85978
dcterms.dateAccepted2022-04-20
rioxxterms.versionofrecord10.3390/metabo12050393
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidZimphango, Chisomo [0000-0002-3147-1150]
dc.contributor.orcidAlimagham, Farah C [0000-0002-2190-1022]
dc.contributor.orcidHutter, Tanya [0000-0001-8106-1830]
dc.identifier.eissn2218-1989
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
cam.issuedOnline2022-04-26


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International