Gill developmental program in the teleost mandibular arch.
eLife Sciences Publications, Ltd
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Thiruppathy, M., Fabian, P., Gillis, J., & Crump, J. G. (2022). Gill developmental program in the teleost mandibular arch.. Elife, 11 https://doi.org/10.7554/eLife.78170
Whereas no known living vertebrate possesses gills derived from the jaw-forming mandibular arch, it has been proposed that the jaw arose through modifications of an ancestral mandibular gill. Here, we show that the zebrafish pseudobranch, which regulates blood pressure in the eye, develops from mandibular arch mesenchyme and first pouch epithelia and shares gene expression, enhancer utilization, and developmental gata3 dependence with the gills. Combined with work in chondrichthyans, our findings in a teleost fish point to the presence of a mandibular pseudobranch with serial homology to gills in the last common ancestor of jawed vertebrates, consistent with a gill origin of vertebrate jaws.
Short Report, Developmental Biology, Evolutionary Biology, Pseudobranch, Gill, jaw, mandibular arch, cranial neural crest, Zebrafish
National Institute of Dental and Craniofacial Research (5R35DE027550)
National Institute of Dental and Craniofacial Research (5K99DE029858)
National Institute of Dental and Craniofacial Research (1F31DE030706)
Royal Society (UF130182)
Royal Society (URF\R\191007)
External DOI: https://doi.org/10.7554/eLife.78170
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338602