Animal number versus maximum tumour volume: an example of reduction and refinement trade-off in the 3Rs.
Bertrand, Henri GMJ
Lab Anim (NY)
Springer Science and Business Media LLC
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Couturier, D., & Bertrand, H. G. (2022). Animal number versus maximum tumour volume: an example of reduction and refinement trade-off in the 3Rs.. Lab Anim (NY) https://doi.org/10.1038/s41684-022-01006-y
In this correspondence, we discuss the trade-off that exists between the reduction and refinement principles of the 3Rs in tumour growth studies. We show, by means of a power analysis considering a realistic setting, that an increase in the maximum tolerated tumour volume leads to a decrease in animal number. We therefore argue that the reduction and refinement principles must be assessed as a function of one another for the determination of appropriate humane and scientific endpoints during ethical review processes.
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External DOI: https://doi.org/10.1038/s41684-022-01006-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338620
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