Animal number versus maximum tumour volume: an example of reduction and refinement trade-off in the 3Rs.
Bertrand, Henri GMJ
Lab Anim (NY)
Springer Science and Business Media LLC
MetadataShow full item record
Couturier, D., & Bertrand, H. G. (2022). Animal number versus maximum tumour volume: an example of reduction and refinement trade-off in the 3Rs.. Lab Anim (NY) https://doi.org/10.1038/s41684-022-01006-y
In this correspondence, we discuss the trade-off that exists between the reduction and refinement principles of the 3Rs in tumour growth studies. We show, by means of a power analysis considering a realistic setting, that an increase in the maximum tolerated tumour volume leads to a decrease in animal number. We therefore argue that the reduction and refinement principles must be assessed as a function of one another for the determination of appropriate humane and scientific endpoints during ethical review processes.
Animal Experimentation, Animal Testing Alternatives, Animal Welfare, Animals, Tumor Burden
External DOI: https://doi.org/10.1038/s41684-022-01006-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338620
All Rights Reserved
Licence URL: http://www.rioxx.net/licenses/all-rights-reserved
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: firstname.lastname@example.org