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dc.contributor.authorCouturier, Dominique-Laurent
dc.contributor.authorBertrand, Henri GMJ
dc.date.accessioned2022-06-29T23:30:16Z
dc.date.available2022-06-29T23:30:16Z
dc.date.issued2022-08
dc.identifier.issn0093-7355
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338620
dc.description.abstractIn this correspondence, we discuss the trade-off that exists between the reduction and refinement principles of the 3Rs in tumour growth studies. We show, by means of a power analysis considering a realistic setting, that an increase in the maximum tolerated tumour volume leads to a decrease in animal number. We therefore argue that the reduction and refinement principles must be assessed as a function of one another for the determination of appropriate humane and scientific endpoints during ethical review processes.
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleAnimal number versus maximum tumour volume: an example of reduction and refinement trade-off in the 3Rs.
dc.typeArticle
dc.publisher.departmentCancer Research Uk Cambridge Institute
dc.date.updated2022-06-28T13:19:33Z
prism.publicationDate2022
prism.publicationNameLab Anim (NY)
dc.identifier.doi10.17863/CAM.86033
dcterms.dateAccepted2022-06-10
rioxxterms.versionofrecord10.1038/s41684-022-01006-y
rioxxterms.versionAM
dc.contributor.orcidCouturier, Dominique-Laurent [0000-0001-5774-5036]
dc.identifier.eissn1548-4475
rioxxterms.typeJournal Article/Review
cam.issuedOnline2022-07-01
cam.orpheus.success2022-06-29 - Embargo set during processing via Fast-track
cam.depositDate2022-06-28
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-01-01


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