Research data supporting "Developmental programming of mitochondrial substrate metabolism in skeletal muscle of adult sheep by cortisol exposure before birth. Insert dataset web link when assigned"
Davies, Katie L
Camm, Emily J
Smith, Danielle J
Forhead, Alison J
Murray, Andrew J
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Davies, K. L., Camm, E. J., Smith, D. J., Miles, J., Forhead, A. J., Murray, A. J., & Fowden, A. (2022). Research data supporting "Developmental programming of mitochondrial substrate metabolism in skeletal muscle of adult sheep by cortisol exposure before birth. Insert dataset web link when assigned" [Dataset]. https://doi.org/10.17863/CAM.85778
Respiratory, gene and protein expression data for adult sheep muscle exposed to cortisol in utero together with biometry and hormonal data Excel spread sheet containing the data presented in the publication below that investigated the effects of prenatal cortisol infusion on mitochondrial function in two skeletal muscles (Biceps femoris, BF, and Semitendinosus, ST) of the adult sheep compared to the effects of prenatal saline infusion. The spread sheet contain tabs for tabulated data of the absolute values for (1) metabolite information on the fetuses during infusion and metabolite and hormonal data on the adults at the time of postnatal study, (2) the biometry of the fetuses and adults at the end of the study and the biochemical composition of their muscles, (3) cortisol concentrations for the cortisol and saline infused fetuses during infusion, (4) gene expression for myosin heavy chain protein isoforms for the fetal BF muscle, (5) gene expression for myosin heavy chain protein isoforms for the fetal ST muscle, (6) gene expression for genes involved in mitochondrial biogenesis and efficiency of oxidative phosphorylation in adult BF muscle, (7) gene expression for genes involved in mitochondrial biogenesis and efficiency of oxidative phosphorylation in adult ST muscle, (8), Western blot data for abundance of the electron transfer Complexes in the adult BF and ST muscles and (9) fetal and adult respiratory rates (oxygen consumption) by BF and ST muscles normalized to citrate synthase activity as a marker of muscle mitochondrial content. Abbreviations are given on each tab. See main manuscript for more details.
Cortisol, Development, Programming, mitochondria
BBSRC grant number BB/P019048/1
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This record's DOI: https://doi.org/10.17863/CAM.85778
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/