Lipid metabolism is dysregulated in a mouse model of diabetes.
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Abstract
Much evidence for diabetes mellitus being associated with dysregulated lipid metabolism has been accrued from studies using blood plasma. However, the systemic dysregulation these results point to is not understood. This study used Lipid Traffic Analysis on data from a mouse model of diabetes to test the hypothesis that the systemic control of lipid metabolism differed in a model of diabetes. This provided eidence for changes in the systemic control of both triglyceride and phospholipid metabolism that were not attributable to dietary intake. This supports the conclusion that diabetes is a systemic condition associated with dysregulated lipid metabolism through several pathways.
Publication Date
2022-05-31
Online Publication Date
2022-05-31
Acceptance Date
2022-04-01
Keywords
Lipid metabolism, Lipid traffic analysis, T2DM, Animals, Diabetes Mellitus, Disease Models, Animal, Lipid Metabolism, Metabolomics, Mice, Triglycerides
Journal Title
Metabolomics
Journal ISSN
1573-3882
1573-3890
1573-3890
Volume Title
18
Publisher
Springer
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M027252/1)