Lipid metabolism is dysregulated in a mouse model of diabetes.

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Authors
  Furse, Samuel
Publication Date
2022-05-31
Journal Title
Metabolomics
ISSN
1573-3882
Publisher
Springer
Volume
18
Issue
6
Language
eng
Type
Article
This Version
VoR
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Citation
Furse, S. (2022). Lipid metabolism is dysregulated in a mouse model of diabetes.. Metabolomics, 18 (6) https://doi.org/10.1007/s11306-022-01884-w
Abstract
Much evidence for diabetes mellitus being associated with dysregulated lipid metabolism has been accrued from studies using blood plasma. However, the systemic dysregulation these results point to is not understood. This study used Lipid Traffic Analysis on data from a mouse model of diabetes to test the hypothesis that the systemic control of lipid metabolism differed in a model of diabetes. This provided eidence for changes in the systemic control of both triglyceride and phospholipid metabolism that were not attributable to dietary intake. This supports the conclusion that diabetes is a systemic condition associated with dysregulated lipid metabolism through several pathways.
Keywords
T2DM, lipid metabolism, Lipid Traffic Analysis, Animals, Mice, Diabetes Mellitus, Disease Models, Animal, Triglycerides, Lipid Metabolism, Metabolomics
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M027252/1)
Identifiers
PMC9156495, 35641694
External DOI: https://doi.org/10.1007/s11306-022-01884-w
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338697
Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International