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Sensitivity analysis for calibrated inverse probability-of-censoring weighted estimators under non-ignorable dropout.

Published version
Peer-reviewed

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Abstract

Inverse probability of censoring weighting is a popular approach to handling dropout in longitudinal studies. However, inverse probability-of-censoring weighted estimators (IPCWEs) can be inefficient and unstable if the weights are estimated by maximum likelihood. To alleviate these problems, calibrated IPCWEs have been proposed, which use calibrated weights that directly optimize covariate balance in finite samples rather than the weights from maximum likelihood. However, the existing calibrated IPCWEs are all based on the unverifiable assumption of sequential ignorability and sensitivity analysis strategies under non-ignorable dropout are lacking. In this paper, we fill this gap by developing an approach to sensitivity analysis for calibrated IPCWEs under non-ignorable dropout. A simple technique is proposed to speed up the computation of bootstrap and jackknife confidence intervals and thus facilitate sensitivity analyses. We evaluate the finite-sample performance of the proposed methods using simulations and apply our methods to data from an international inception cohort study of systemic lupus erythematosus. An R Markdown tutorial to demonstrate the implementation of the proposed methods is provided.

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Keywords

Covariate balancing, informative dropout, inverse probability weighting, longitudinal data, missing not at random, Cohort Studies, Computer Simulation, Humans, Longitudinal Studies, Probability

Journal Title

Stat Methods Med Res

Conference Name

Journal ISSN

0962-2802
1477-0334

Volume Title

31

Publisher

SAGE Publications
Sponsorship
MRC (unknown)
MRC (unknown)