Redefining intestinal immunity with single-cell transcriptomics.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
James, Kylie Renee
Elmentaite, Rasa
Teichmann, Sarah Amalia
Hold, Georgina Louise
Abstract
The intestinal immune system represents the largest collection of immune cells in the body and is continually exposed to antigens from food and the microbiota. Here we discuss the contribution of single-cell transcriptomics in shaping our understanding of this complex system. We consider the impact on resolving early intestine development, engagement with the neighbouring microbiota, diversity of intestinal immune cells, compartmentalisation within the intestines and interactions with non-immune cells. Finally, we offer a perspective on open questions about gut immunity that evolving single-cell technologies are well placed to address.
Description
Keywords
Gastrointestinal Tract, Immune System, Intestines, Microbiota, Transcriptome
Journal Title
Mucosal Immunol
Conference Name
Journal ISSN
1933-0219
1935-3456
1935-3456
Volume Title
15
Publisher
Elsevier BV