Dominant Stickler Syndrome.
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Soh, Z., Richards, A. J., McNinch, A., Alexander, P., Martin, H., & Snead, M. (2022). Dominant Stickler Syndrome.. Genes (Basel), 13 (6. ARTN 1089), 1089. https://doi.org/10.3390/genes13061089
The Stickler syndromes are a group of genetic connective tissue disorders associated with an increased risk of rhegmatogenous retinal detachment, deafness, cleft palate, and premature arthritis. This review article focuses on the molecular genetics of the autosomal dominant forms of the disease. Pathogenic variants in COL2A1 causing Stickler syndrome usually result in haploinsufficiency of the protein, whereas pathogenic variants of type XI collagen more usually exert dominant negative effects. The severity of the disease phenotype is thus dependent on the location and nature of the mutation, as well as the normal developmental role of the respective protein.
COL11A1, COL2A1, Stickler syndrome, giant retinal tear, retinal detachment, vitreous, Arthritis, Connective Tissue Diseases, Craniofacial Abnormalities, Eye Diseases, Hereditary, Hearing Loss, Sensorineural, Humans, Osteochondrodysplasias, Pedigree, Retinal Detachment
External DOI: https://doi.org/10.3390/genes13061089
This record's URL: https://www.repository.cam.ac.uk/handle/1810/339057
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/