Physico-Chemical Characterisation of Disease-Related Protein-Protein Interactions in Solution
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Abstract
Current standard techniques for investigating protein-protein interactions require volumes and concentrations significantly higher than those relevant under physiological conditions. Microfluidic diffusional sizing offers an alternative method for investigating protein-protein interactions and protein assembly under physiological conditions and has been applied to investigate a wide range of protein properties, functions, and interactions. In this thesis,
current approaches are further extended and their applicability to various interactions related to human diseases is shown. Specifically, recent work is described which makes use of microfluidic techniques combined with chemical kinetic and thermodynamic analyses to study the mechanism of the disaggregation of
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Dobson, Christopher M