A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure
Ferreira, Fabio S.
Valk, Sofie L.
Eickhoff, Simon B.
Nature Publishing Group UK
MetadataShow full item record
Nicolaisen-Sobesky, E., Mihalik, A., Kharabian-Masouleh, S., Ferreira, F. S., Hoffstaedter, F., Schwender, H., Maleki Balajoo, S., et al. (2022). A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure. https://doi.org/10.1038/s42003-022-04244-5
Identifying associations between interindividual variability in brain structure and behaviour requires large cohorts, multivariate methods, out-of-sample validation and, ideally, out-of-cohort replication. Moreover, the influence of nature vs nurture on brain-behaviour associations should be analysed. We analysed associations between brain structure (grey matter volume, cortical thickness, and surface area) and behaviour (spanning cognition, emotion, and alertness) using regularized canonical correlation analysis and a machine learning framework that tests the generalisability and stability of such associations. The replicability of brain-behaviour associations was assessed in two large, independent cohorts. The load of genetic factors on these associations was analysed with heritability and genetic correlation. We found one heritable and replicable latent dimension linking cognitive-control/executive-functions and positive affect to brain structural variability in areas typically associated with higher cognitive functions, and with areas typically associated with sensorimotor functions. These results revealed a major axis of interindividual behavioural variability linking to a whole-brain structural pattern.
Article, /631/378/2649, /631/477/2811, /59/57, article
External DOI: https://doi.org/10.1038/s42003-022-04244-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/347723
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: firstname.lastname@example.org