Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia.


Type
Article
Change log
Authors
Abstract

Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.

Description
Keywords
Blood Vessels, Cell Adhesion, Humans, Leukemia, Myeloid, Acute
Journal Title
Nat Commun
Conference Name
Journal ISSN
2041-1723
2041-1723
Volume Title
11
Publisher
Springer Science and Business Media LLC