The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents

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Spreckley, Eleanor 
Rodriguez, Aina Fernandez 
Viscomi, Carlo 
Alamshah, Amin 

Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analysing the different effects on feeding behaviour of peptide YY3-36 (PYY3-36), lithium chloride, glucagon-like peptide 1 (GLP-1), and leptin shows the precise behavioural changes caused by each anorectic agent. Our analysis demonstrates that the changes in feeding behaviour evoked by the anorectic agents investigated do not mimic the behaviour of well-fed animals and that the intermeal interval is influenced by fullness. We show how robust homeostatic control of feeding thwarts attempts to reduce food intake and how this might be overcome. In silico experiments suggest that introducing a minimum intermeal interval or modulating upper gut emptying can be as effective as anorectic drug administration.

Research Article, Research and analysis methods, Biology and life sciences, Medicine and health sciences, Social sciences, Physical sciences
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Biotechnology and Biological Sciences Research Council (BB/J014575/1)
Engineering and Physical Sciences Research Council (EP/N014529/1)
National Centre for the Replacement Refinement & Reduction of Animals in Research (NC/K500379/1)
Biotechnology and Biological Sciences Research Council (BB/I001816/1)
Diabetes UK (18/0005886)