Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor

Accepted version
Repository URI
https://www.repository.cam.ac.uk/handle/1810/348642
Repository DOI
https://doi.org/10.17863/CAM.96069
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Accepted version (2.29 MB) (Embargoed until: 2024-12-31)
Type
Article
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Authors
Willems, Henriëtte MG 
Edwards, Simon 
Boffey, Helen K 
Chawner, Stephen J 
Green, Christopher 
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Abstract

jats:pThe phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) play a central role in regulating cell signalling pathways and, as such, have become therapeutic targets for diseases such as cancer, neurodegeneration and immunological disorders....</jats:p>

Description
Keywords
3404 Medicinal and Biomolecular Chemistry, 34 Chemical Sciences, Cancer, Neurodegenerative, 5.1 Pharmaceuticals, 1 Underpinning research, 1.1 Normal biological development and functioning, 5 Development of treatments and therapeutic interventions, Cancer
Journal Title
RSC Medicinal Chemistry
Conference Name
Journal ISSN
2632-8682
2632-8682
Volume Title
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
https://doi.org/10.1039/d3md00039g
Rights
All Rights Reserved
Sponsorship
Alzheimer's Research UK (ARUK-2015DDI-CAM)
Alzheimer’s Research UK (grant: ARUK-2015DDI-CAM), with support from the ALBORADA Trust. The ALBORADA Drug Discovery Institute is core funded by Alzheimer’s Research UK (registered charity No. 1077089 and SC042474)
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Cambridge University Research Outputs