Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor
Accepted version
Peer-reviewed
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Repository DOI
Change log
Authors
Willems, Henriëtte MG
Edwards, Simon
Boffey, Helen K
Chawner, Stephen J
Green, Christopher
Abstract
jats:pThe phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) play a central role in regulating cell signalling pathways and, as such, have become therapeutic targets for diseases such as cancer, neurodegeneration and immunological disorders....</jats:p>
Description
Keywords
3404 Medicinal and Biomolecular Chemistry, 34 Chemical Sciences, Cancer, Neurodegenerative, 5.1 Pharmaceuticals, 1 Underpinning research, 1.1 Normal biological development and functioning, 5 Development of treatments and therapeutic interventions, Cancer
Journal Title
RSC Medicinal Chemistry
Conference Name
Journal ISSN
2632-8682
2632-8682
2632-8682
Volume Title
Publisher
Royal Society of Chemistry (RSC)
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Sponsorship
Alzheimer's Research UK (ARUK-2015DDI-CAM)
Alzheimer’s Research UK (grant: ARUK-2015DDI-CAM), with support from the ALBORADA Trust. The ALBORADA Drug Discovery Institute is core funded by Alzheimer’s Research UK (registered charity No. 1077089 and SC042474)