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Neutralisation of SARS-CoV-2 by anatomical embalming solutions.

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cam.issuedOnline2021-10-11
dc.contributor.authorQuondamatteo, Fabio
dc.contributor.authorCorzo-Leon, Dora E
dc.contributor.authorBrassett, Cecilia
dc.contributor.authorColquhoun, Ian
dc.contributor.authorDavies, David C
dc.contributor.authorDockery, Peter
dc.contributor.authorGrenham, Sue
dc.contributor.authorGuild, Simon
dc.contributor.authorHunter, Amanda
dc.contributor.authorJones, James
dc.contributor.authorLee, Thomas C
dc.contributor.authorTracey, Chris
dc.contributor.authorWilkinson, Tracey
dc.contributor.authorMunro, Carol A
dc.contributor.authorGillingwater, Thomas H
dc.contributor.authorParson, Simon H
dc.contributor.orcidDavies, David C [0000-0001-9198-6685]
dc.contributor.orcidDockery, Peter [0000-0001-5103-6589]
dc.contributor.orcidJones, James [0000-0002-1997-4257]
dc.contributor.orcidLee, Thomas C [0000-0002-0408-3726]
dc.contributor.orcidGillingwater, Thomas H [0000-0002-0306-5577]
dc.contributor.orcidParson, Simon H [0000-0002-8848-8738]
dc.date.accessioned2021-11-25T17:29:18Z
dc.date.available2021-11-25T17:29:18Z
dc.date.issued2021-11
dc.description.abstractTeaching and learning anatomy by using human cadaveric specimens has been a foundation of medical and biomedical teaching for hundreds of years. Therefore, the majority of institutions that teach topographical anatomy rely on body donation programmes to provide specimens for both undergraduate and postgraduate teaching of gross anatomy. The COVID-19 pandemic has posed an unprecedented challenge to anatomy teaching because of the suspension of donor acceptance at most institutions. This was largely due to concerns about the potential transmissibility of the SARS-CoV-2 virus and the absence of data about the ability of embalming solutions to neutralise the virus. Twenty embalming solutions commonly used in institutions in the United Kingdom and Ireland were tested for their ability to neutralise SARS-CoV-2, using an established cytotoxicity assay. All embalming solutions tested neutralised SARS-CoV-2, with the majority of solutions being effective at high-working dilutions. These results suggest that successful embalming with the tested solutions can neutralise the SARS-CoV-2 virus, thereby facilitating the safe resumption of body donation programmes and cadaveric anatomy teaching.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.78638
dc.identifier.eissn1469-7580
dc.identifier.issn0021-8782
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331191
dc.languageeng
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1111/joa.13549
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbody donation
dc.subjectcadaver
dc.subjectfixation
dc.subjectpreservation
dc.subjectCOVID-19
dc.subjectCadaver
dc.subjectCells, Cultured
dc.subjectDisease Transmission, Infectious
dc.subjectEmbalming
dc.subjectFixatives
dc.subjectFormaldehyde
dc.subjectHumans
dc.subjectPandemics
dc.subjectSARS-CoV-2
dc.subjectTissue Fixation
dc.titleNeutralisation of SARS-CoV-2 by anatomical embalming solutions.
dc.typeArticle
dcterms.dateAccepted2021-09-06
prism.publicationDate2021
prism.publicationNameJ Anat
rioxxterms.licenseref.startdate2021-10-11
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1111/joa.13549

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