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Short-term gain, long-term pain: the senescence life cycle and cancer.

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cam.issuedOnline2019-02-01
cam.orpheus.successThu Jan 30 10:53:00 GMT 2020 - Embargo updated
dc.contributor.authorChan, Adelyne Sue Li
dc.contributor.authorNarita, Masashi
dc.contributor.orcidChan, Adelyne Sue Li [0000-0003-2214-0306]
dc.contributor.orcidNarita, Masashi [0000-0001-7764-577X]
dc.date.accessioned2019-01-18T00:30:59Z
dc.date.available2019-01-18T00:30:59Z
dc.date.issued2019-02-01
dc.description.abstractOriginally thought of as a stress response end point, the view of cellular senescence has since evolved into one encompassing a wide range of physiological and pathological functions, including both protumorignic and antitumorigenic features. It has also become evident that senescence is a highly dynamic and heterogenous process. Efforts to reconcile the beneficial and detrimental features of senescence suggest that physiological functions require the transient presence of senescent cells in the tissue microenvironment. Here, we propose the concept of a physiological "senescence life cycle," which has pathological consequences if not executed in its entirety.
dc.description.sponsorshipThe Narita laboratory is funded by a Cancer Research UK Cambridge Institute Core Grant (C14303/A17197). Masashi Narita is also supported by Cancer Research UK Early Detection Pump Priming award (C20/A20976), Medical Research Council (MR/R010013/1) and the Tokyo Tech World Research Hub Initiative (WRHI).
dc.format.mediumPrint
dc.identifier.doi10.17863/CAM.35478
dc.identifier.eissn1549-5477
dc.identifier.issn0890-9369
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288162
dc.languageeng
dc.language.isoeng
dc.publisherCold Spring Harbor Laboratory
dc.publisher.urlhttp://dx.doi.org/10.1101/gad.320937.118
dc.subjectcancer
dc.subjectepigenetics
dc.subjectinflammation
dc.subjectsenescence
dc.subjectCell Cycle
dc.subjectCellular Microenvironment
dc.subjectCellular Senescence
dc.subjectEpigenomics
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectPrecancerous Conditions
dc.subjectTelomere Shortening
dc.titleShort-term gain, long-term pain: the senescence life cycle and cancer.
dc.typeArticle
dcterms.dateAccepted2018-11-14
prism.endingPage143
prism.issueIdentifier3-4
prism.publicationDate2019
prism.publicationNameGenes Dev
prism.startingPage127
prism.volume33
pubs.funder-project-idCancer Research UK (CB4210)
pubs.funder-project-idCancer Research UK (C14303/A17197)
pubs.funder-project-idMedical Research Council (MR/R010013/1)
pubs.funder-project-idCancer Research UK (C20/A20976)
rioxxterms.licenseref.startdate2019-02
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1101/gad.320937.118

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