Short-term gain, long-term pain: the senescence life cycle and cancer.
cam.issuedOnline | 2019-02-01 | |
cam.orpheus.success | Thu Jan 30 10:53:00 GMT 2020 - Embargo updated | |
dc.contributor.author | Chan, Adelyne Sue Li | |
dc.contributor.author | Narita, Masashi | |
dc.contributor.orcid | Chan, Adelyne Sue Li [0000-0003-2214-0306] | |
dc.contributor.orcid | Narita, Masashi [0000-0001-7764-577X] | |
dc.date.accessioned | 2019-01-18T00:30:59Z | |
dc.date.available | 2019-01-18T00:30:59Z | |
dc.date.issued | 2019-02-01 | |
dc.description.abstract | Originally thought of as a stress response end point, the view of cellular senescence has since evolved into one encompassing a wide range of physiological and pathological functions, including both protumorignic and antitumorigenic features. It has also become evident that senescence is a highly dynamic and heterogenous process. Efforts to reconcile the beneficial and detrimental features of senescence suggest that physiological functions require the transient presence of senescent cells in the tissue microenvironment. Here, we propose the concept of a physiological "senescence life cycle," which has pathological consequences if not executed in its entirety. | |
dc.description.sponsorship | The Narita laboratory is funded by a Cancer Research UK Cambridge Institute Core Grant (C14303/A17197). Masashi Narita is also supported by Cancer Research UK Early Detection Pump Priming award (C20/A20976), Medical Research Council (MR/R010013/1) and the Tokyo Tech World Research Hub Initiative (WRHI). | |
dc.format.medium | ||
dc.identifier.doi | 10.17863/CAM.35478 | |
dc.identifier.eissn | 1549-5477 | |
dc.identifier.issn | 0890-9369 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/288162 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Cold Spring Harbor Laboratory | |
dc.publisher.url | http://dx.doi.org/10.1101/gad.320937.118 | |
dc.subject | cancer | |
dc.subject | epigenetics | |
dc.subject | inflammation | |
dc.subject | senescence | |
dc.subject | Cell Cycle | |
dc.subject | Cellular Microenvironment | |
dc.subject | Cellular Senescence | |
dc.subject | Epigenomics | |
dc.subject | Humans | |
dc.subject | Neoplasms | |
dc.subject | Precancerous Conditions | |
dc.subject | Telomere Shortening | |
dc.title | Short-term gain, long-term pain: the senescence life cycle and cancer. | |
dc.type | Article | |
dcterms.dateAccepted | 2018-11-14 | |
prism.endingPage | 143 | |
prism.issueIdentifier | 3-4 | |
prism.publicationDate | 2019 | |
prism.publicationName | Genes Dev | |
prism.startingPage | 127 | |
prism.volume | 33 | |
pubs.funder-project-id | Cancer Research UK (CB4210) | |
pubs.funder-project-id | Cancer Research UK (C14303/A17197) | |
pubs.funder-project-id | Medical Research Council (MR/R010013/1) | |
pubs.funder-project-id | Cancer Research UK (C20/A20976) | |
rioxxterms.licenseref.startdate | 2019-02 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review | |
rioxxterms.version | AM | |
rioxxterms.versionofrecord | 10.1101/gad.320937.118 |
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