Models and Tools for Studying Enteroendocrine Cells.


Type
Article
Change log
Authors
Goldspink, Deborah A 
Gribble, Fiona M 
Abstract

Gut hormones produced by gastrointestinal enteroendocrine cells modulate key physiological processes including glucose homeostasis and food intake, making them potential therapeutic candidates to treat obesity and diabetes. Understanding the function of enteroendocrine cells and the molecular mechanisms driving hormone production is a key step toward mobilizing endogenous hormone reserves in the gut as a therapeutic strategy. In this review, we will discuss the variety of ex vivo and in vitro model systems driving this research and their contributions to our current understanding of nutrient-sensing mechanisms in enteroendocrine cells.

Description
Keywords
Animals, Eating, Endocrinology, Enteroendocrine Cells, Gastrointestinal Hormones, Gastrointestinal Tract, Homeostasis, Humans, Models, Biological
Journal Title
Endocrinology
Conference Name
Journal ISSN
0013-7227
1945-7170
Volume Title
159
Publisher
The Endocrine Society
Sponsorship
Medical Research Council (MC_UU_12012/3)
Wellcome Trust (106262/Z/14/Z)
Medical Research Council (MC_UU_12012/5)
MRC (MC_UU_00014/3)
MRC (MC_UU_00014/5)