Theoretical models of complex between herpes simplex virus 1 proteins pUL16 and pUL21

Change log

Theoretical models of herpes simplex virus (HSV)-1 protein pUL16 in complex with the C-terminal domain of HSV-1 pUL21. Models were generated using AlphaFold2-Multimer version 2.2.2. The template sequences were HSV-1 pUL16 (UniProt ID P10200) and HSV-1 pUL21C (residues 275–535, UniProt ID F8RG07). The top 25 models produced by AlphaFold2 (ranked_0.pdb to ranked_24.pdb) are available (, with associated AlphaFold2 output files ( and to, as are quality statistic plots and raw output (pre-residue pLDDT, plus PAE matrices; and input sequences (HSV_UL16_UL21C-multimer-v2.2.2.fasta). The top model, with protons removed and residues of pUL21 (chain B) renumbered to match the canonical UniProt numbering is also available (pUL16_pUL21C_ranked_0_noH_renumbered.pdb). For more information, see the README.txt file.

Software / Usage instructions
Compressed (zip) files can be extracted using inbuilt operating system tools or 7-zip ( FASTA file (.fasta) can be opened in a text editor or using any general sequence viewing application (e.g. SnapGene, UGene, JalView). PDB format files (.pdb) can be opened in a text editor or viewed using PyMOL ( or ChimeraX ( Text files (.txt) can be opened using operating system tools.
ab initio model, herpes simplex virus, herpesvirus, structural biology, virology
Wellcome Trust (098406/Z/12/B)
A Titan V graphics card used for this research was donated by the NVIDIA Corporation.
Is supplemented by: