Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.

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Gapp, Katharina 
Jawaid, Ali 
Sarkies, Peter 
Bohacek, Johannes 
Pelczar, Pawel 

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

Animals, Animals, Newborn, Cell Line, Tumor, Dark Adaptation, Disease Models, Animal, Energy Intake, Female, Gene Expression Regulation, Male, Maternal Deprivation, Maze Learning, Mice, Mice, Inbred C57BL, MicroRNAs, Oocytes, RNA, Small Interfering, RNA, Small Untranslated, Reaction Time, Spermatozoa, Stress, Psychological
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Nat Neurosci
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Springer Science and Business Media LLC
Wellcome Trust (092096/Z/10/Z)
We thank M. Rassoulzadegan and V. Grandjean for help with the sperm purification, F. Manuella and H. Hörster for assistance with the MSUS paradigm, H. Welzl for help with behavior, G. Vernaz for help with western blotting, R. Tweedie-Cullen and P. Nanni for help with mass spectrometry, A. Patrignani for advice on DNA and RNA quality assessment, and A. Chen and A. Brunner for constructive discussions. This work was supported by the Austrian Academy of Sciences, the University of Zürich, the Swiss Federal Institute of Technology, Roche, the Swiss National Science Foundation, and The National Center of Competence in Research “Neural Plasticity and Repair”. P.S. was supported by a Gonville and Caius College fellowship.