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Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality.

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cam.depositDate2022-05-25
cam.issuedOnline2022-06-16
cam.orpheus.counter3
cam.orpheus.successMon Jun 27 07:19:02 BST 2022 - Embargo updated*
cam.orpheus.successVoR added.
dc.contributor.authorStickels, Christian Philip
dc.contributor.authorNadarajah, Ramesh
dc.contributor.authorGale, Chris P
dc.contributor.authorJiang, Houyuan
dc.contributor.authorSharkey, Kieran J
dc.contributor.authorGibbison, Ben
dc.contributor.authorHolliman, Nick
dc.contributor.authorLombardo, Sara
dc.contributor.authorSchewe, Lars
dc.contributor.authorSommacal, Matteo
dc.contributor.authorSun, Louise
dc.contributor.authorWeir-McCall, Jonathan
dc.contributor.authorCheema, Katherine
dc.contributor.authorRudd, James
dc.contributor.authorMamas, Mamas
dc.contributor.authorErhun, Feryal
dc.contributor.orcidStickels, Christian Philip [0000-0002-5286-9379]
dc.contributor.orcidNadarajah, Ramesh [0000-0001-9895-9356]
dc.contributor.orcidJiang, Houyuan [0000-0002-2466-6929]
dc.contributor.orcidSharkey, Kieran J [0000-0002-7210-9246]
dc.contributor.orcidHolliman, Nick [0000-0003-4418-4908]
dc.contributor.orcidLombardo, Sara [0000-0003-3545-163X]
dc.contributor.orcidSchewe, Lars [0000-0002-3778-262X]
dc.contributor.orcidSommacal, Matteo [0000-0003-2820-2117]
dc.contributor.orcidSun, Louise [0000-0003-3381-3115]
dc.contributor.orcidRudd, James [0000-0003-2243-3117]
dc.contributor.orcidMamas, Mamas [0000-0001-9241-8890]
dc.contributor.orcidErhun, Feryal [0000-0003-0339-7085]
dc.date.accessioned2022-05-25T23:31:02Z
dc.date.available2022-05-25T23:31:02Z
dc.date.issued2022-06-16
dc.date.updated2022-05-25T09:58:44Z
dc.description.abstractOBJECTIVES: To provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect National Health Service (NHS) England waiting list duration and associated mortality. DESIGN: We constructed a mathematical model of the excess waiting list and found the closed-form analytic solution to that model. From published data, we calculated estimates for how the strategies listed under Interventions may affect the time to clear the backlog of patients waiting for treatment and the associated waiting list mortality. SETTING: The NHS in England. PARTICIPANTS: Estimated patients with AS in England. INTERVENTIONS: (1) Increasing the capacity for the treatment of severe AS, (2) converting proportions of cases from surgery to transcatheter aortic valve implantation and (3) a combination of these two. RESULTS: In a capacitated system, clearing the backlog by returning to pre-COVID-19 capacity is not possible. A conversion rate of 50% would clear the backlog within 666 (533-848) days with 1419 (597-2189) deaths while waiting during this time. A 20% capacity increase would require 535 (434-666) days, with an associated mortality of 1172 (466-1859). A combination of converting 40% cases and increasing capacity by 20% would clear the backlog within a year (343 (281-410) days) with 784 (292-1324) deaths while awaiting treatment. CONCLUSION: A strategy change to the management of severe AS is required to reduce the NHS backlog and waiting list deaths during the post-COVID-19 'recovery' period. However, plausible adaptations will still incur a substantial wait to treatment and many hundreds dying while waiting.
dc.description.sponsorshipBG is supported by the NIHR Bristol Biomedical Research Centre at the University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust. JHFR is part-supported by the NIHR Cambridge Biomedical Research Centre, the British Heart Foundation, HEFCE, the EPSRC Cambridge Centre for Mathematics of Information in Healthcare and the Wellcome Trust.
dc.identifier.doi10.17863/CAM.84908
dc.identifier.eissn2044-6055
dc.identifier.issn2044-6055
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337494
dc.language.isoeng
dc.publisherBMJ
dc.publisher.departmentJudge Business School
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality.
dc.typeArticle
dcterms.dateAccepted2022-05-20
prism.publicationNameBMJ Open
pubs.funder-project-idEPSRC (EP/T017961/1)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/N014588/1)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1136/bmjopen-2021-059309

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