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AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials.

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Wheeler, Graham M 
Sweeting, Michael J 
Mander, Adrian P 


In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.



Clinical Trials, Phase I as Topic, Dose-Response Relationship, Drug, Humans, Internet, Maximum Tolerated Dose, Neoplasms, Programming Languages, Research Design, User-Computer Interface

Journal Title

PLoS One

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Public Library of Science (PLoS)
Medical Research Council (MR/L003120/1)
MRC (unknown)
European Research Council (268834)
GMW and APM are supported by the UK Medical Research Council (; grant number G0800860). MJS is supported by a European Research Council Advanced Investigator Award: EPIC-Heart (; grant number 268834), the UK Medical Research Council (grant number MR/L003120/1), the British Heart Foundation (, and the Cambridge National Institute for Health Research Biomedical Research Centre ( The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.