Repository logo
 

Language impairment in progressive supranuclear palsy and corticobasal syndrome

Published version
Peer-reviewed

Change log

Authors

Patterson, Karalyn 

Abstract

Abstract: Although commonly known as movement disorders, progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) may present with changes in speech and language alongside or even before motor symptoms. The differential diagnosis of these two disorders can be challenging, especially in the early stages. Here we review their impact on speech and language. We discuss the neurobiological and clinical-phenomenological overlap of PSP and CBS with each other, and with other disorders including non-fluent agrammatic primary progressive aphasia and primary progressive apraxia of speech. Because language impairment is often an early and persistent problem in CBS and PSP, there is a need for improved methods for language screening in primary and secondary care, and more detailed language assessments in tertiary healthcare settings. Improved language assessment may aid differential diagnosis as well as inform clinical management decisions.

Description

Keywords

Review, Corticobasal syndrome, Language, Progressive supranuclear palsy

Journal Title

Journal of Neurology

Conference Name

Journal ISSN

0340-5354
1432-1459

Volume Title

268

Publisher

Springer Berlin Heidelberg
Sponsorship
Medical Research Council (SUAG/051/101400)
MRC (MR/N025881/1)
Wellcome Trust (103838)