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Local and Universal Action: The Paradoxes of Indole Signalling in Bacteria.

Accepted version
Peer-reviewed

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Authors

Liu, Junyan 
Gaimster, Hannah 
Summers, David K 

Abstract

Indole is a signalling molecule produced by many bacterial species and involved in intraspecies, interspecies, and interkingdom signalling. Despite the increasing volume of research published in this area, many aspects of indole signalling remain enigmatic. There is disagreement over the mechanism of indole import and export and no clearly defined target through which its effects are exerted. Progress is hindered further by the confused and sometimes contradictory body of indole research literature. We explore the reasons behind this lack of consistency and speculate whether the discovery of a new, pulse mode of indole signalling, together with a move away from the idea of a conventional protein target, might help to overcome these problems and enable the field to move forward.

Description

Keywords

antibiotics, bacterial membrane, cytoplasmic pH, indole signalling, persisters, stress response, Biofilms, Biological Transport, Cell Membrane, Escherichia coli, Indoles, Quorum Sensing, Signal Transduction, Stress, Physiological

Journal Title

Trends Microbiol

Conference Name

Journal ISSN

0966-842X
1878-4380

Volume Title

28

Publisher

Elsevier BV
Sponsorship
Leverhulme Trust (RPG-2015-184)
Innovate UK (971621)
Biotechnology and Biological Sciences Research Council (BB/F002912/1)
Medical Research Council (1933099)
The Leverhulme Trust, UK (RPG-2015-184)