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Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions

Published version
Peer-reviewed

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Authors

Smith, Alexander C. W.  ORCID logo  https://orcid.org/0000-0001-7724-6234
Jonkman, Sietse 
Difeliceantonio, Alexandra G.  ORCID logo  https://orcid.org/0000-0002-7155-6060
O’Connor, Richard M. 

Abstract

Abstract: Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully learn a new lever-press response to earn food rewards. Post-learning chemogenetic inhibition of aDLS disrupts consolidation of the new instrumental response. Similarly, post-learning infusion of the protein synthesis inhibitor anisomycin into the aDLS disrupts consolidation of the new response. Activity of D1 receptor-expressing medium spiny neurons (D1-MSNs) increases and D2-MSNs activity decreases in the aDLS during consolidation. Chemogenetic inhibition of D1-MSNs in aDLS disrupts the consolidation process whereas D2-MSN inhibition strengthens consolidation but blocks the expression of previously learned habit-like responses. These findings suggest that D1-MSNs in the aDLS encode new instrumental actions whereas D2-MSNs oppose this new learning and instead promote expression of habitual actions.

Description

Keywords

Article, /631/378/1595/1396, /631/378/1662, /13, /14, /14/63, /38/44, /42, /45, /64/86, /64/60, article

Journal Title

Nature Communications

Conference Name

Journal ISSN

2041-1723

Volume Title

12

Publisher

Nature Publishing Group UK
Sponsorship
U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) (DA025983)