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Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise.

Accepted version
Peer-reviewed

Type

Article

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Authors

Aydin, Sibel Z 
Direskeneli, Haner 
Merkel, Peter A 
International Delphi on Disease Activity Assessment in Large-vessel Vasculitis 

Abstract

OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials. METHODS: A Delphi survey including 99 items was circulated among international experts for 3 rounds. RESULTS: Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. CONCLUSION: This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

Description

Keywords

GIANT CELL ARTERITIS, LARGE VESSEL, OUTCOMES, TAKAYASU ARTERITIS, VASCULITIS, Delphi Technique, Giant Cell Arteritis, Humans, Severity of Illness Index, Takayasu Arteritis

Journal Title

J Rheumatol

Conference Name

Journal ISSN

0315-162X
1499-2752

Volume Title

44

Publisher

The Journal of Rheumatology

Rights

All rights reserved