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The retroviral RNA dimer linkage: different structures may reflect different roles.


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Authors

Greatorex, Jane 

Abstract

Retroviruses are unique among virus families in having dimeric genomes. The RNA sequences and structures that link the two RNA molecules vary, and these differences provide clues as to the role of this feature in the viral lifecycles. This review draws upon examples from different retroviral families. Differences and similarities in both secondary and tertiary structure are discussed. The implication of varying roles for the dimer linkage in related viruses is considered.

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Keywords

Animals, Dimerization, Genetic Linkage, Genetic Variation, Genome, Viral, HIV-1, Humans, RNA, Viral, RNA-Directed DNA Polymerase, Recombination, Genetic, Retroviridae

Journal Title

Retrovirology

Conference Name

Journal ISSN

1742-4690
1742-4690

Volume Title

Publisher

Springer Science and Business Media LLC