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A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice

Published version
Peer-reviewed

Change log

Authors

Piedrafita, Gabriel  ORCID logo  https://orcid.org/0000-0001-8701-1084
Kostiou, Vasiliki 
Wabik, Agnieszka 
Fernandez-Antoran, David 

Abstract

Abstract: In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additional transgenic assay to follow cell division in mouse esophagus and the epidermis at multiple body sites. We find that proliferating cells divide at a similar rate, and place bounds on the distribution cell cycle times. By including these results in a common analytic approach, we show that data from eight lineage tracing experiments is consistent with tissue maintenance by a single population of proliferating cells. The outcome of a given cell division is unpredictable but, on average, the likelihood of producing proliferating and differentiating cells is equal, ensuring cellular homeostasis. These findings are key to understanding squamous epithelial homeostasis and carcinogenesis.

Description

Keywords

Article, /631/114, /631/532, /14, /14/1, /14/19, /9, /13, /64/60, article

Journal Title

Nature Communications

Conference Name

Journal ISSN

2041-1723

Volume Title

11

Publisher

Nature Publishing Group UK
Sponsorship
Cancer Research UK (CRUK) (C609/A27326, C/609/A17257)
Wellcome Trust (Wellcome) (098051, 296194)
Royal Society (UF130039)