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Sepsis-3 criteria in AmsterdamUMCdb: open-source code implementation

Published version
Peer-reviewed

Type

Article

Change log

Abstract

Sepsis is a major healthcare problem with substantial mortality and a common reason for admission to the intensive care unit (ICU). For this reason, the management of sepsis is an important area of ICU research. A number of large-scale, freely-accessible ICU databases are available for observational research and the robust identification of septic patients in such data sets is crucial for research purposes, particularly for comparative studies between critical care sub-populations which may vary around the world. However, data structures are poorly standardised due to inevitable variances in clinical electronic health record system vendor and implementation as well as research database design choices. Robust and well-documented cohort selection (such as patients with sepsis) is crucial for reproducible research. In this work, we operationalise the Sepsis-3 definition on the AmsterdamUMCdb, a recently published large European ICU database, publishing open-access code for wider use by critical care researchers. This is the Author Accepted Manuscript, accepted after peer review by GigaByte.

Description

Keywords

46 Information and Computing Sciences, 4609 Information Systems, Sepsis, Infectious Diseases, Hematology, 7.3 Management and decision making, Inflammatory and immune system, Infection, 3 Good Health and Well Being

Journal Title

Gigabyte

Conference Name

Journal ISSN

2709-4715
2709-4715

Volume Title

Publisher

GigaScience Press
Sponsorship
EPSRC (2089662)
Engineering and Physical Sciences Research Council (EP/S515334/1)