Repository logo
 

Deep learning-based diffusion tensor cardiac magnetic resonance reconstruction: a comparison study.

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Huang, Jiahao 
Ferreira, Pedro F 
Wang, Lichao 
Wu, Yinzhe 
Aviles-Rivero, Angelica I 

Abstract

In vivo cardiac diffusion tensor imaging (cDTI) is a promising Magnetic Resonance Imaging (MRI) technique for evaluating the microstructure of myocardial tissue in living hearts, providing insights into cardiac function and enabling the development of innovative therapeutic strategies. However, the integration of cDTI into routine clinical practice poses challenging due to the technical obstacles involved in the acquisition, such as low signal-to-noise ratio and prolonged scanning times. In this study, we investigated and implemented three different types of deep learning-based MRI reconstruction models for cDTI reconstruction. We evaluated the performance of these models based on the reconstruction quality assessment, the diffusion tensor parameter assessment as well as the computational cost assessment. Our results indicate that the models discussed in this study can be applied for clinical use at an acceleration factor (AF) of × 2 and × 4 , with the D5C5 model showing superior fidelity for reconstruction and the SwinMR model providing higher perceptual scores. There is no statistical difference from the reference for all diffusion tensor parameters at AF × 2 or most DT parameters at AF × 4 , and the quality of most diffusion tensor parameter maps is visually acceptable. SwinMR is recommended as the optimal approach for reconstruction at AF × 2 and AF × 4 . However, we believe that the models discussed in this study are not yet ready for clinical use at a higher AF. At AF × 8 , the performance of all models discussed remains limited, with only half of the diffusion tensor parameters being recovered to a level with no statistical difference from the reference. Some diffusion tensor parameter maps even provide wrong and misleading information.

Description

Acknowledgements: This study was supported in part by the UKRI Future Leaders Fellowship (MR/V023799/1), BHF (RG/19/1/34160), the ERC IMI (101005122), the H2020 (952172), the MRC (MC/PC/21013), the Royal Society (IEC/NSFC/211235), the NVIDIA Academic Hardware Grant Program, Wellcome Leap Dynamic Resilience, EPSRC (EP/V029428/1, EP/S026045/1, EP/T003553/1, EP/N014588/1, EP/T017961/1), Imperial College London President’s PhD Scholarship and the Cambridge Mathematics of Information in Healthcare Hub (CMIH) Partnership Fund.


Funder: This study was supported in part by the UKRI Future Leaders Fellowship (MR/V023799/1), BHF (RG/19/1/34160), the ERC IMI (101005122), the H2020 (952172), the MRC (MC/PC/21013), the Royal Society (IEC/NSFC/211235), the NVIDIA Academic Hardware Grant Program, EPSRC (EP/V029428/1, EP/S026045/1, EP/T003553/1, EP/N014588/1, EP/T017961/1), and the Cambridge Mathematics of Information in Healthcare Hub (CMIH) Partnership Fund.

Keywords

CNN, Cardiac diffusion tensor, Deep learning, MRI reconstruction, Transformer, Diffusion Tensor Imaging, Deep Learning, Algorithms, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Diffusion Magnetic Resonance Imaging

Journal Title

Sci Rep

Conference Name

Journal ISSN

2045-2322
2045-2322

Volume Title

14

Publisher

Springer Science and Business Media LLC