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Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Pearson, Selina A 
Vancollie, Valerie E  ORCID logo  https://orcid.org/0000-0003-1547-1975

Abstract

Adult-onset hearing loss is very common, but we know little about the underlying molecular pathogenesis impeding the development of therapies. We took a genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly generated mouse mutants using a sensitive electrophysiological test, the auditory brainstem response (ABR). We review here the findings from this screen. Thirty-eight unexpected genes associated with raised thresholds were detected from our unbiased sample of 1,211 genes tested, suggesting extreme genetic heterogeneity. A wide range of auditory pathophysiologies was found, and some mutant lines showed normal development followed by deterioration of responses, revealing new molecular pathways involved in progressive hearing loss. Several of the genes were associated with the range of hearing thresholds in the human population and one, SPNS2, was involved in childhood deafness. The new pathways required for maintenance of hearing discovered by this screen present new therapeutic opportunities.

Description

Keywords

Acoustic Stimulation, Adult, Animals, Anion Transport Proteins, Auditory Perception, Child, Electrophysiological Phenomena, Evoked Potentials, Auditory, Brain Stem, Female, Genetic Association Studies, Hearing, Hearing Loss, Humans, Male, Mice, Mice, Inbred C57BL

Journal Title

PLoS Biol

Conference Name

Journal ISSN

1544-9173
1545-7885

Volume Title

17

Publisher

Public Library of Science (PLoS)