Repository logo
 

Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques

Published version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/382756

Repository DOI

Thumbnail Image

Files

Published version (3.23 MB)
 Bibliographic metadata (63.52 KB)
Primary Published version (1.23 MB)
 Published version (269.88 KB)

Type

Other

Change log

Authors

Abstract

The influence of Lewy body (LB) and tau co-pathologies is increasingly acknowledged as putatively affecting neurodegeneration and clinical phenotypes. Here, we injected rhesus macaques with LB fractions or/and tau seeds derived from patients brains into distinct brain areas connected to the mesencephalon. Compared to control macaques, we observed increased mesencephalic staining of pathological α-synuclein and tau, as well as nigrostriatal dopaminergic neuronal loss, with a cumulative effect of co-pathology.

Description

Acknowledgements: This project received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 116060 (IMPRiND), supported by the European Union’s Horizon 2020 research and innovation program and EFPIA. This work was also supported by the Bettencourt-Schueller Foundation (CCA-recherche Inserm-Bettencourt), the PSP-France Foundation, the Center of Excellence for Neurodegenerative Diseases in Bordeaux (BIND), the French government in the framework of the University of Bordeaux’s IdEx “Investments for the Future” programme/GPR BRAIN_2030, and by a grant from the Michael J Fox Foundation (Project Grant No. 2019-008814). The University of Bordeaux and the Centre National de la Recherche Scientifique provided infrastructural support. M.D. is a recipient of a Clément Fayat Foundation fellowship (France). W.A.M. is a Lister Institute Fellow supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (206248/Z/17/Z).


Funder: Clément Fayat Foundation


Funder: Michael J. Fox Foundation for Parkinson's Research; doi: https://doi.org/10.13039/100000864


Funder: Bettencourt-Schueller Foundation


Funder: PSP-France Foundation


Funder: Center of Excellence for Neurodegenerative Diseases in Bordeaux (BIND)

Keywords

Is Part Of

Publisher

Nature Publishing Group UK

Publisher DOI

https://doi.org/10.1038/s41531-025-00938-9

Rights and licensing

undefined
Except where otherwised noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsorship
the Innovative Medicines Initiative 2 Joint Undertaking (116060 (IMPRiND), 116060 (IMPRiND), 116060 (IMPRiND))
Wellcome Trust and the Royal Society (206248/Z/17/Z)
French government in the framework of the University of Bordeaux’s IdEx “Investments for the Future” program (GPR BRAIN_2030)

Collections

Jisc Publications Router