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Mouse models of colorectal cancer as preclinical models.


Type

Article

Change log

Authors

McIntyre, Rebecca E 
Buczacki, Simon JA 
Arends, Mark J 
Adams, David J 

Abstract

In this review, we discuss the application of mouse models to the identification and pre-clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large-scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross-species comparative 'omics-based approaches to this problem. We highlight recent progress in modelling late-stage disease using mice, and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection.

Description

Keywords

colorectal cancer, disease biomarker, mouse model, ome and omics, target identification, target validation, Animals, Antineoplastic Agents, Colorectal Neoplasms, Genes, Neoplasm, Humans, Molecular Targeted Therapy, Neoplasms, Experimental, Species Specificity, Xenograft Model Antitumor Assays

Journal Title

Bioessays

Conference Name

Journal ISSN

0265-9247
1521-1878

Volume Title

37

Publisher

Wiley
Sponsorship
Cancer Research Uk (None)
REM, SJAB, MJA and DJA are funded by Cancer Research UK.