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Cytoskeletal control of the secretory immune synapse.

Accepted version
Peer-reviewed

Type

Article

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Authors

Douanne, Tiphaine 
Griffiths, Gillian M 

Abstract

The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation. Two key mechanisms are the polarisation of the centrosome and rapid actin dynamics across the immune synapses that form between interacting immune cells. In recent years it has become clear that different immune cells utilise a diversity of immune synapses that modify these mechanisms in order to optimise specialised modes of secretion. Here we describe some of the latest research, focusing on regulation by centrosomal and actin dynamics in a variety of immune cells.

Description

Keywords

Actin, Centrosome, Immune synapse, Immunodeficiencies, Secretion, Actins, Centrosome, Cytoskeleton, Immunological Synapses, Synapses

Journal Title

Curr Opin Cell Biol

Conference Name

Journal ISSN

0955-0674
1879-0410

Volume Title

71

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (217100/Z/19/Z)