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The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs.

Published version
Peer-reviewed

Repository DOI


Type

Article

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Authors

Hossain, AS Md Mukarram  ORCID logo  https://orcid.org/0000-0003-2654-8982
Miller, Eric L 
Bruchmann, Sebastian  ORCID logo  https://orcid.org/0000-0001-8721-5386
Balmer, Andrew J 

Abstract

The expansion and intensification of livestock production is predicted to promote the emergence of pathogens. As pathogens sometimes jump between species, this can affect the health of humans as well as livestock. Here, we investigate how livestock microbiota can act as a source of these emerging pathogens through analysis of Streptococcus suis, a ubiquitous component of the respiratory microbiota of pigs that is also a major cause of disease on pig farms and an important zoonotic pathogen. Combining molecular dating, phylogeography, and comparative genomic analyses of a large collection of isolates, we find that several pathogenic lineages of S. suis emerged in the 19th and 20th centuries, during an early period of growth in pig farming. These lineages have since spread between countries and continents, mirroring trade in live pigs. They are distinguished by the presence of three genomic islands with putative roles in metabolism and cell adhesion, and an ongoing reduction in genome size, which may reflect their recent shift to a more pathogenic ecology. Reconstructions of the evolutionary histories of these islands reveal constraints on pathogen emergence that could inform control strategies, with pathogenic lineages consistently emerging from one subpopulation of S. suis and acquiring genes through horizontal transfer from other pathogenic lineages. These results shed light on the capacity of the microbiota to rapidly evolve to exploit changes in their host population and suggest that the impact of changes in farming on the pathogenicity and zoonotic potential of S. suis is yet to be fully realized.

Description

Keywords

Streptococcus suis, bacterial pathogens, comparative genomics, livestock pathogens, pathogen emergence, Animals, Humans, Swine, Streptococcal Infections, Farms, Swine Diseases, Virulence, Streptococcus suis, Livestock

Journal Title

Proc Natl Acad Sci U S A

Conference Name

Journal ISSN

0027-8424
1091-6490

Volume Title

120

Publisher

Proceedings of the National Academy of Sciences
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/L018934/1)
Wellcome Trust (109385/Z/15/Z)
European Commission Horizon 2020 (H2020) Societal Challenges (727966)
MRC (MR/V032836/1)
BBSRC (2113638)
Medical Research Council (1933099)
Royal Society (DH140195)
Biotechnology and Biological Sciences Research Council (BB/S013784/1)
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