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Pericoronary and periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis and atherosclerosis.

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dc.contributor.authorWall, Christopher
dc.contributor.authorHuang, Yuan
dc.contributor.authorLe, Elizabeth P V
dc.contributor.authorĆorović, Andrej
dc.contributor.authorUy, Christopher P
dc.contributor.authorGopalan, Deepa
dc.contributor.authorMa, Chuoxin
dc.contributor.authorManavaki, Roido
dc.contributor.authorFryer, Tim D
dc.contributor.authorAloj, Luigi
dc.contributor.authorGraves, Martin J
dc.contributor.authorTombetti, Enrico
dc.contributor.authorAriff, Ben
dc.contributor.authorBambrough, Paul
dc.contributor.authorHoole, Stephen P
dc.contributor.authorRusk, Rosemary A
dc.contributor.authorJayne, David R
dc.contributor.authorDweck, Marc R
dc.contributor.authorNewby, David
dc.contributor.authorFayad, Zahi A
dc.contributor.authorBennett, Martin R
dc.contributor.authorPeters, James E
dc.contributor.authorSlomka, Piotr
dc.contributor.authorDey, Damini
dc.contributor.authorMason, Justin C
dc.contributor.authorRudd, James H F
dc.contributor.authorTarkin, Jason M
dc.contributor.orcidGopalan, Deepa [0000-0001-8079-205X]
dc.contributor.orcidHoole, Stephen P [0000-0002-3530-3808]
dc.contributor.orcidSlomka, Piotr [0000-0002-6110-938X]
dc.contributor.orcidDey, Damini [0000-0003-2236-6970]
dc.contributor.orcidMason, Justin C [0000-0001-7783-1660]
dc.contributor.orcidTarkin, Jason M [0000-0002-9132-120X]
dc.date.accessioned2021-11-22T14:49:26Z
dc.date.available2021-11-22T14:49:26Z
dc.date.issued2021-08-06
dc.date.updated2021-11-22T14:49:25Z
dc.description.abstract<h4>Aims</h4>To examine pericoronary adipose tissue (PCAT) and periaortic adipose tissue (PAAT) density on coronary computed tomography angiography for assessing arterial inflammation in Takayasu arteritis (TAK) and atherosclerosis.<h4>Methods and results</h4>PCAT and PAAT density was measured in coronary (<i>n</i> = 1016) and aortic (<i>n</i> = 108) segments from 108 subjects [TAK + coronary artery disease (CAD), <i>n</i> = 36; TAK, <i>n</i> = 18; atherosclerotic CAD, <i>n</i> = 32; matched controls, <i>n</i> = 22]. Median PCAT and PAAT densities varied between groups (mPCAT: <i>P</i> < 0.0001; PAAT: <i>P</i> = 0.0002). PCAT density was 7.01 ± standard error of the mean (SEM) 1.78 Hounsfield Unit (HU) higher in coronary segments from TAK + CAD patients than stable CAD patients (<i>P</i> = 0.0002), and 8.20 ± SEM 2.04 HU higher in TAK patients without CAD than controls (<i>P</i> = 0.0001). mPCAT density was correlated with Indian Takayasu Clinical Activity Score (<i>r</i> = 0.43, <i>P</i> = 0.001) and C-reactive protein (<i>r</i> = 0.41, <i>P</i> < 0.0001) and was higher in active vs. inactive TAK (<i>P</i> = 0.002). mPCAT density above -74 HU had 100% sensitivity and 95% specificity for differentiating active TAK from controls [area under the curve = 0.99 (95% confidence interval 0.97-1)]. The association of PCAT density and coronary arterial inflammation measured by <sup>68</sup>Ga-DOTATATE positron emission tomography (PET) equated to an increase of 2.44 ± SEM 0.77 HU in PCAT density for each unit increase in <sup>68</sup>Ga-DOTATATE maximum tissue-to-blood ratio (<i>P</i> = 0.002). These findings remained in multivariable sensitivity analyses adjusted for potential confounders.<h4>Conclusions</h4>PCAT and PAAT density are higher in TAK than atherosclerotic CAD or controls and are associated with clinical, biochemical, and PET markers of inflammation. Owing to excellent diagnostic accuracy, PCAT density could be useful as a clinical adjunct for assessing disease activity in TAK.
dc.identifier.doi10.17863/CAM.78374
dc.identifier.issn2752-4191
dc.identifier.otherPMC8508012
dc.identifier.other34661196
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330931
dc.languageeng
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceessn: 2752-4191
dc.sourcenlmid: 9918282081406676
dc.subjectcoronary artery disease
dc.subjectTakayasu Arteritis
dc.subjectPericoronary Adipose Tissue Density
dc.titlePericoronary and periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis and atherosclerosis.
dc.typeArticle
prism.issueIdentifier2
prism.publicationNameEuropean heart journal open
prism.volume1
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1093/ehjopen/oeab019

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