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Autophagy and neurodegeneration

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Rubinsztein, DC 


Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. Finally, we briefly describe some of the signaling pathways that may be amenable to therapeutic targeting for these goals.



31 Biological Sciences, 32 Biomedical and Clinical Sciences, 42 Health Sciences, Rare Diseases, Neurodegenerative, Orphan Drug, Neurosciences, 2.1 Biological and endogenous factors, 2 Aetiology, Neurological, Animals, Autophagy, Humans, Neurodegenerative Diseases, Protein Kinase Inhibitors, TOR Serine-Threonine Kinases

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American Society for Clinical Investigation
Wellcome Trust (100140/Z/12/Z)
Wellcome Trust (095317/Z/11/A)
We are grateful for support from a Wellcome Trust Principal Research Fellowship (to D.C. Rubinsztein), a Wellcome Trust/MRC Strategic Grant on Neurodegeneration (to D.C. Rubinsztein), a Sims Scholarship from the FEE Fund and JB Fund (to R.A. Frake), the NIHR Biomedical Research Centre at Addenbrooke’s Hospital, the Tau Consortium, and Alzheimer’s Research UK.