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Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Curran, Scott 
Strandkvist, Charlotte 
Bathmann, Jasper 
de Gennes, Marc 

Abstract

Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively studied, less is known about AJ dynamics in other circumstances. Here, we study AJ dynamics in an epithelium that undergoes a gradual increase in packing order, without concomitant large-scale changes in tissue size or shape. We find that neighbor exchange events are driven by stochastic fluctuations in junction length, regulated in part by junctional actomyosin. In this context, the developmental increase of isotropic junctional actomyosin reduces the rate of neighbor exchange, contributing to tissue order. We propose a model in which the local variance in tension between junctions determines whether actomyosin-based forces will inhibit or drive the topological transitions that either refine or deform a tissue.

Description

Keywords

Drosophila, Myosin, cadherin, epithelia, junction fluctuations, morphogenesis, neighbor exchange, tissue mechanics, tissue refinement, vertex model, Actomyosin, Adherens Junctions, Animals, Cadherins, Drosophila Proteins, Drosophila melanogaster, Epithelium, Myosin Type II

Journal Title

Dev Cell

Conference Name

Journal ISSN

1534-5807
1878-1551

Volume Title

43

Publisher

Elsevier BV